A CONTROLLED-STUDY ON THE EFFECTS OF N - 3 FATTY-ACIDS ON LIPID AND GLUCOSE-METABOLISM IN NON-INSULIN-DEPENDENT DIABETIC-PATIENTS
A CONTROLLED-STUDY ON THE EFFECTS OF N - 3 FATTY-ACIDS ON LIPID AND GLUCOSE-METABOLISM IN NON-INSULIN-DEPENDENT DIABETIC-PATIENTS
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DOI：
10.1016/0021-9150(91)90233-s
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发表时间：
1991-03-01
期刊：
影响因子：
5.3
通讯作者：
RICCARDI, G
中科院分区：
文献类型：
--
作者：
ANNUZZI, G;RIVELLESE, A;RICCARDI, G
8名男性非胰岛素依赖型糖尿病患者参加了一项双盲随机交叉研究(每期2周)，评估每天补充10g鱼油对糖脂代谢的影响。由于极低密度脂蛋白的降低，鱼油降低了空腹血清甘油三酯浓度(1.4+/-0.2vs.1.9+/-0.2mmol.L，P<；0.025)。低密度脂蛋白胆固醇浓度反而升高(3.4+/-0.3vs.2.8/-0.3 mm ol/L，P<；0.025)，极低密度脂蛋白甘油三酯和低密度脂蛋白的净变化呈负相关(r=-0.86，P<；0.001)。服用鱼油和安慰剂后，血浆游离脂肪酸浓度和周转率([H-3]棕榈酸法)相似。补充鱼油对空腹血糖(8.1+/-1.1vs.8.5+/-1.2 mmoL/L)和日均血糖(9.4+/-3.2vs.9.3+/-3.5mmoL/L)无显著影响。在高血糖钳夹期间，葡萄糖刺激的血浆胰岛素反应在早期和稳定期均未受到鱼油的显著影响。胰岛素敏感性(M/I指数)也没有变化。总而言之，这项研究表明，饮食中补充鱼油降低了非胰岛素依赖型糖尿病患者的血浆甘油三酯水平，增加了极低密度脂蛋白到低密度脂蛋白的转化率，在这种变化中发挥了作用。使用该剂量的鱼油，在血糖控制、胰岛素分泌和胰岛素敏感性方面没有相关的变化。
Eight male non-insulin-dependent diabetic patients participated in a double-blind randomized cross-over study (2 weeks for each period) evaluating the effects of 10 g/day fish oil dietary supplementation on glucose and lipid metabolism. Fasting serum triglyceride concentrations were decreased by fish oil because of a reduction in VLDL (1.4 +/- 0.2 vs. 1.9 +/- 0.2 mmol/l, P < 0.025). LDL cholesterol concentration was instead increased (3.4 +/- 0.3 vs. 2.8 +/- 0.3 mmol/l, P < 0.025) and net changes in VLDL triglyceride and in LDL cholesterol were inversely correlated (r = -0.86, P < 0.001). Plasma free fatty acids concentrations and turnover rate ([H-3]palmitate method) were similar after fish oil and placebo. Fish oil supplement did not induce significant changes in fasting blood glucose (8.1 +/- 1.1 vs. 8.5 +/- 1.2 mmol/l) and average daily blood glucose (BG) (9.4 +/- 3.2 vs. 9.3 +/- 3.5 mmol/l). Glucose stimulated plasma insulin response during a hyperglycemic clamp was not significantly influenced by fish oil both in the early phase and during steady state. Insulin sensitivity (M/I index) was also unchanged. In conclusion, this study shows that a dietary supplement of fish oil decreases plasma triglyceride levels in non-insulin-dependent diabetic patients, an increased conversion rate of VLDL to LDL playing a role in this change. With this dosage of fish oil no relevant variations in glycemic control, insulin secretion and insulin sensitivity occurred.