Multifunctional Synthetic Poly(l-Glutamic Acid)–Based Cancer Therapeutic and Imaging Agents
Multifunctional Synthetic Poly(l-Glutamic Acid)–Based Cancer Therapeutic and Imaging Agents
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DOI：
10.2310/7290.2011.00007
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发表时间：
2011-01
影响因子：
2.8
通讯作者：
M. Melancon;Chun Xing Li
中科院分区：
文献类型：
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作者：
M. Melancon;Chun Xing Li
现代高分子化学已经导致了许多生物相容性合成聚合物的产生，这些聚合物作为药物和成像剂的有效载体已经被越来越多地研究。合成的生物相容性聚合物已被用于改善小分子量治疗剂和成像剂的功效。此外，多个靶向抗癌剂和/或成像报告物可以连接到单个聚合物链，允许多功能和/或多模态治疗和分子成像。在单个聚合物链中具有抗癌药物和成像报告子允许聚合物药物递送系统的药代动力学的非侵入性实时可视化，这可以揭示和解释体内药物递送的复杂机制及其与药效学的相关性。本文综述了使用合成的生物相容性聚合物聚（L-谷氨酸）（PG）作为一种有效的载体的癌症治疗和成像剂。本文综述并更新了我们最近的研究使用PG作为药物输送和分子成像的平台，包括最近的临床研究结果与PG-紫杉醇（PG-TXL），结合PG-TXL与放射治疗，PG-TXL的作用机制，和非侵入性可视化在体内传递的聚合物共轭物与对比增强磁共振成像，光学成像，和多模态成像。
Modern polymer chemistry has led to the generation of a number of biocompatible synthetic polymers that have been increasingly studied as efficient carriers for drugs and imaging agents. Synthetic biocompatible polymers have been used to improve the efficacy of both small-molecular-weight therapeutics and imaging agents. Furthermore, multiple targeted anticancer agents and/or imaging reporters can be attached to a single polymer chain, allowing multifunctional and/or multimodality therapy and molecular imaging. Having both an anticancer drug and an imaging reporter in a single polymer chain allows noninvasive real-time visualization of the pharmacokinetics of polymeric drug delivery systems, which can uncover and explain the complicated mechanisms of in vivo drug delivery and their correlation to pharmacodynamics. This review examines the use of the synthetic biocompatible polymer poly(l-glutamic acid) (PG) as an efficient carrier of cancer therapeutics and imaging agents. This review summarizes and updates our recent research on the use of PG as a platform for drug delivery and molecular imaging, including recent clinical findings with respect to PG-paclitaxel (PG-TXL), the combination of PG-TXL with radiotherapy, mechanisms of action of PG-TXL, and noninvasive visualization of in vivo delivery of polymeric conjugates with contrast-enhanced magnetic resonance imaging, optical imaging, and multimodality imaging.