Integrin-Dependent Cell-Matrix Adhesion in Endothelial Health and Disease.
Integrin-Dependent Cell-Matrix Adhesion in Endothelial Health and Disease.
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内皮健康和疾病中整合素依赖性细胞粘附。
DOI：
10.1161/circresaha.122.322332
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发表时间：
2023-02-03
影响因子：
20.1
通讯作者：
Margadant, Coert
中科院分区：
文献类型：
--
作者：
Aman, Jurjan;Margadant, Coert
内皮是一个动态的，半渗透层内衬所有血管，调节血管形成和屏障功能。内皮屏障的适当组成和功能是流体稳态所必需的，并且以屏障破坏为特征的临床病症与严重发病率和高死亡率相关。内皮屏障的性质是由细胞连接和细胞内信号转导途径控制的细胞骨架，但最近的见解表明，整合素介导的细胞-基质粘附和信号转导在内皮屏障调节中的作用越来越重要。在这里，我们讨论了以内皮屏障破坏为特征的疾病，并概述了内皮细胞-基质粘附复合物的组成和相关的信号通路、它们与细胞-细胞连接以及与其他受体的串扰。我们进一步提出了最近的见解细胞基质粘附在发展和成熟/成人内皮的各种血管床的作用，并讨论如何动态调节和营业额的细胞基质粘附调节内皮屏障功能（病理）生理条件下，如血管生成，炎症和血流动力学应激。最后，由于与血管渗漏相关的临床状况仍然缺乏直接治疗，我们专注于如何了解内皮细胞-基质粘附可能提供新的治疗靶点，并讨论当前的翻译挑战和未来的前景。
The endothelium is a dynamic, semipermeable layer lining all blood vessels, regulating blood vessel formation and barrier function. Proper composition and function of the endothelial barrier are required for fluid homeostasis, and clinical conditions characterized by barrier disruption are associated with severe morbidity and high mortality rates. Endothelial barrier properties are regulated by cell–cell junctions and intracellular signaling pathways governing the cytoskeleton, but recent insights indicate an increasingly important role for integrin-mediated cell–matrix adhesion and signaling in endothelial barrier regulation. Here, we discuss diseases characterized by endothelial barrier disruption, and provide an overview of the composition of endothelial cell–matrix adhesion complexes and associated signaling pathways, their crosstalk with cell–cell junctions, and with other receptors. We further present recent insights into the role of cell–matrix adhesions in the developing and mature/adult endothelium of various vascular beds, and discuss how the dynamic regulation and turnover of cell–matrix adhesions regulates endothelial barrier function in (patho)physiological conditions like angiogenesis, inflammation and in response to hemodynamic stress. Finally, as clinical conditions associated with vascular leak still lack direct treatment, we focus on how understanding of endothelial cell–matrix adhesion may provide novel targets for treatment, and discuss current translational challenges and future perspectives.
影响因子：
9.2
作者：
Li, Ran;Pendergast, Ann Marie
通讯作者：
Pendergast, Ann Marie
影响因子：
3.7
作者：
Chung FT;Lin HC;Kuo CH;Yu CT;Chou CL;Lee KY;Kuo HP;Lin SM
通讯作者：
Lin SM