Haematogenous cytokeratin 20 mRNA as a predictive marker for recurrence in oral cancer patients
Haematogenous cytokeratin 20 mRNA as a predictive marker for recurrence in oral cancer patients
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DOI：
10.1038/sj.bjc.6690377
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发表时间：
1999-05-01
影响因子：
8.8
通讯作者：
Sato, R
中科院分区：
文献类型：
--
作者：
Kawamata, H;Uchida, D;Sato, R
应用逆转录聚合酶链反应（RT-PCR）检测口腔鳞癌（SCC）患者外周血中细胞角蛋白20（CK 20）mRNA的表达。12例口腔鳞癌患者中11例RT-PCR结果阳性。然而，血行CK 20 mRNA与转移之间没有明确的关系。经过初步治疗后，所有接受测试的无肿瘤幸存者的RT-PCR结果均呈阴性。外周血CK 20 mRNA可作为口腔鳞癌复发的标志物，但不能作为口腔鳞癌转移的标志物。
We examined the expression of cytokeratin 20 (CK20) mRNA in the peripheral blood of oral squamous cell carcinoma (SCC) patients by reverse transcriptase polymerase chain reaction (RT-PCR). Eleven out of 12 oral SCC patients showed positive RT-PCR results. However, there is no clear relationship between the haematogenous CK20 mRNA and the metastasis. After initial treatment, all of the tumour-free survivors tested showed negative RT-PCR results. CK20 mRNA in peripheral blood can be used as a marker for tumour recurrence but not for metastasis in oral SCC patients.