Dual targeting of plastid division protein FtsZ to chloroplasts and the cytoplasm
Dual targeting of plastid division protein FtsZ to chloroplasts and the cytoplasm
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DOI：
10.1038/sj.embor.7400238
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发表时间：
2004-09-01
期刊：
影响因子：
7.7
通讯作者：
Reski, R
中科院分区：
文献类型：
--
作者：
Kiessling, J;Martin, A;Reski, R
FtsZ是一种在原核细胞分裂位点组装成环的亲核形成蛋白。由于FtsZ和微管蛋白具有一些生化和结构上的相似性，FtsZ被认为是微管蛋白的祖先。叶绿体-植物细胞内共生细菌的后代-也含有FtsZ。与真细菌相比，植物具有几种不同的FtsZ同种型。到目前为止，这些异构体只涉及丝状结构，环和网络，叶绿体内。在这里，我们证明了一种新的FtsZ异构体的苔藓立碗藓不仅位于叶绿体，而且在细胞质中，组装成环在两个细胞室。这些研究结果包括第一次报告真核FtsZ亚型的胞质定位，并表明这种蛋白质可能连接细胞和细胞器分裂至少在苔藓。
FtsZ is a filament-forming protein that assembles into a ring at the division site of prokaryotic cells. As FtsZ and tubulin share several biochemical and structural similarities, FtsZ is regarded as the ancestor of tubulin. Chloroplasts - the descendants of endosymbiotic bacteria within plant cells - also harbour FtsZ. In contrast to eubacteria, plants have several different FtsZ isoforms. So far, these isoforms have only been implicated with filamentous structures, rings and networks, inside chloroplasts. Here, we demonstrate that a novel FtsZ isoform in the moss Physcomitrella patens is located not only in chloroplasts but also in the cytoplasm, assembling into rings in both cell compartments. These findings comprise the first report on cytosolic localization of a eukaryotic FtsZ isoform, and indicate that this protein might connect cell and organelle division at least in moss.