Epstein-Barr virus and infectious mononucleosis.
Epstein-Barr virus and infectious mononucleosis.
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爱泼斯坦-巴尔病毒和传染性单核细胞增多症。
DOI：
10.1056/nejm197302012880512
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
G. Henle
中科院分区：
文献类型：
--
作者：
W. Henle;G. Henle
最近，人们对爱泼斯坦-巴尔病毒（EB病毒）是传染性单核细胞增多症病因的压倒性证据进行了审查。1但由于许多问题仍未得到解答，人们仍然对该病毒的致病作用表示怀疑。其中，尚未从患者的口咽部分离出EBV，也未证明EBV特异性IgM抗体应答是原发性感染的体征。由于病毒的特殊性和技术问题，这些缺陷现在至少部分得到了补救。EB病毒显然只限于在淋巴系细胞内复制，甚至……
The overwhelming evidence that the Epstein–Barr virus (EBV) is the cause of infectious mononucleosis has recently been reviewed.1 Yet doubts are still being expressed regarding the causative role of the virus because a number of questions have remained unanswered. Among others, EBV had not been isolated from the oropharynx of patients and no EBV-specific IgM antibody responses had been demonstrated as a sign of primary infections. These deficiencies, owing to peculiarities of the virus and technical problems, have now, at least in part, been remedied. EBV is apparently restricted for its replication to cells of the lymphoid series, and even . . .