Endoplasmic Reticulum Structure and Interconnections with Other Organelles
Endoplasmic Reticulum Structure and Interconnections with Other Organelles
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DOI：
10.1101/cshperspect.a013227
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发表时间：
2013-04-01
影响因子：
7.2
通讯作者：
Voeltz, Gia K.
中科院分区：
文献类型：
--
作者：
English, Amber R.;Voeltz, Gia K.
内质网（ER）是一个巨大的、连续的膜结合细胞器，由功能和结构不同的结构域组成，包括核膜、外周管状内质网、外周池以及质膜上的许多膜接触位点、线粒体、高尔基体、核内体和过氧化物酶体。这些结构域是多种细胞过程所必需的，包括蛋白质和脂质的合成，钙水平的调节，以及与er膜接触部位的各种细胞器的大分子交换。内质网保持其独特的整体结构，无论动力学或转移在内质网细胞器接触。在这篇综述中，我们描述了影响急诊室结构的众多因素。
The endoplasmic reticulum (ER) is a large, continuous membrane-bound organelle comprised of functionally and structurally distinct domains including the nuclear envelope, peripheral tubular ER, peripheral cisternae, and numerous membrane contact sites at the plasma membrane, mitochondria, Golgi, endosomes, and peroxisomes. These domains are required for multiple cellular processes, including synthesis of proteins and lipids, calcium level regulation, and exchange of macromolecules with various organelles at ER-membrane contact sites. The ER maintains its unique overall structure regardless of dynamics or transfer at ER-organelle contacts. In this review, we describe the numerous factors that contribute to the structure of the ER.