Levels-of-processing effects in first-degree relatives of individuals with schizophrenia
Levels-of-processing effects in first-degree relatives of individuals with schizophrenia
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DOI：
10.1016/j.biopsych.2006.07.006
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发表时间：
2007-05-15
影响因子：
10.6
通讯作者：
Barch, Deanna M.
中科院分区：
文献类型：
--
作者：
Bonner-Jackson, Aaron;Csernansky, John G.;Barch, Deanna M.
背景资料：精神分裂症患者的一级亲属表现出与其患病亲属相似但不那么严重的认知障碍。我们已经证明，通过提供有益的编码策略，精神分裂症患者的记忆障碍可以得到改善，前额叶皮层（PFC）活动增加。目前的研究使用了类似的范式，以确定精神分裂症患者的兄弟姐妹（SIB）是否也显示出有益的编码策略时大脑活动的增加。方法：21名SIB和38名健康对照受试者的兄弟姐妹进行功能性磁共振成像扫描，同时进行深（抽象/具体判断）和浅（正字法判断）编码。受试者，然后给予再认记忆test.Results：组没有不同的编码或识别准确性，和SIB受益于深编码到类似的程度作为对照subjects.The SIB显示深编码相关的活动，在一些PFC区域通常在语义处理过程中激活。然而，SIB表现出更多的活动比对照组的PFC的三个亚区（左BA 44和BA 47双边）。结论：精神分裂症患者的sibery受益于支持性的口头编码条件。与精神分裂症患者一样，在深度言语编码过程中，SIB也在更多的前额叶皮质亚区中表现出与任务相关的活动增加。
Background: First-degree relatives of individuals with schizophrenia show cognitive impairments that are similar to but less severe than their ill relatives. We have shown that memory impairments can be improved and prefrontal cortical (PFC) activity increased in individuals with schizophrenia by providing beneficial encoding strategies.The current study used a similar paradigm to determine whether siblings of individuals with schizophrenia (SIBs) also show increases in brain activity when presented with beneficial encoding strategies.Methods: Twenty-one SIBs and 38 siblings of healthy comparison subjects underwent functional magnetic resonance imaging scans while engaged in deep (abstract/concrete judgments) and shallow (orthographic judgments) encoding. Subjects were then given a recognition memory test.Results: The groups did not differ on encoding or recognition accuracy, and the SIBs benefited from deep encoding to a similar degree as control subjects.The SIBs showed deep encoding-related activity in a number of PFC regions typically activated during semantic processing. However, SIBs showed more activity than control subjects in three subregions of PFC (left BA 44 & BA 47 bilaterally).Conclusions: Siblings of individuals with schizophrenia benefit from supportive verbal encoding conditions. Like individuals with schizophrenia, SIBs also show increased task-related activity in a larger number of PFC subregions than control subjects during deep verbal encoding.