Sortilin levels are associated with peripheral arterial disease in type 2 diabetic subjects
Sortilin levels are associated with peripheral arterial disease in type 2 diabetic subjects
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DOI：
10.1186/s12933-019-0805-5
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发表时间：
2019-01-11
影响因子：
9.3
通讯作者：
Flex, Andrea
中科院分区：
文献类型：
--
作者：
Biscetti, Federico;Bonadia, Nicola;Flex, Andrea
背景分拣蛋白是一种分子量为95-kDa的蛋白质，最近发现其与循环胆固醇浓度和发生显著动脉粥样硬化疾病的终生风险有关。分拣蛋白存在于不同的细胞类型中，并在血液中循环。与对照受试者相比，在冠状动脉粥样硬化患者中发现了更高的循环分拣蛋白浓度。分拣蛋白浓度受他汀类药物治疗的影响。MethodsWe招募了未接受过他汀类药物治疗的2型糖尿病患者，我们进行了一项横断面研究，以评估分拣蛋白水平与无他汀类药物的糖尿病患者人群中临床显著下肢外周动脉疾病（PAD）的存在之间的相关性。74例有临床意义的PAD。后一组的分拣蛋白浓度显著高于前一组（1.61 ± 0.54ng/mL vs 0.67 ± 0.30ng/mL，P
BackgroundSortilin is a 95-kDa protein which has recently been linked to circulating cholesterol concentration and lifetime risk of developing significant atherosclerotic disease. Sortilin is found inside different cell types and circulating in blood. Higher circulating sortilin concentration has been found in patients with coronary atherosclerosis compared to control subjects. Sortilin concentration is influenced by statin therapy.MethodsWe enrolled statin-naive subjects with type 2 diabetes mellitus and we performed a cross-sectional study to evaluate the association between sortilin levels and the presence of clinically significant lower limb peripheral artery disease (PAD) in a population of statin-free diabetic subjects.ResultsOut of the 154 patients enrolled in our study, 80 patients were free from PAD, while 74 had clinically significant PAD. Sortilin concentration was significantly higher in the latter group compared to the former (1.610.54ng/mL versus 0.67 +/- 0.30ng/mL, P