Drosophila Chemoreceptors: A Molecular Interface Between the Chemical World and the Brain.
Drosophila Chemoreceptors: A Molecular Interface Between the Chemical World and the Brain.
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DOI：
10.1016/j.tig.2015.09.005
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Carlson JR
中科院分区：
文献类型：
--
作者：
Joseph RM;Carlson JR
接受化学物质是生存所必需的。捕食、交配和躲避捕食者依赖于对感官线索的检测。果蝇含有不同的化学感受器家族，可以检测气味、味觉物质、信息素和有害刺激，包括OR、Gr、IR、PPK和Trp家族的受体。我们回顾了了解苍蝇化学感受的最新进展，包括新受体的鉴定，受体新的生物学功能的发现，以及受体在意想不到的地方的定位。我们讨论了尚未解决的主要问题，并提出了未来可能特别成熟的发现领域，包括这些受体在驱动对动物的生存和繁殖至关重要的回路和行为方面的作用。
Chemoreception is essential for survival. Feeding, mating, and avoidance of predators depend on detection of sensory cues. Drosophila contains diverse families of chemoreceptors that detect odors, tastants, pheromones, and noxious stimuli, including receptors of the Or, Gr, IR, Ppk, and Trp families. We consider recent progress in understanding chemoreception in the fly, including the identification of new receptors, the discovery of novel biological functions for receptors, and the localization of receptors in unexpected places. We discuss major unsolved problems and suggest areas that may be particularly ripe for future discoveries, including the roles of these receptors in driving the circuits and behaviors that are essential to the survival and reproduction of the animal.