A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet
A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet
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DOI：
10.1096/fj.03-0159hyp
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发表时间：
2003-09-01
期刊：
影响因子：
4.8
通讯作者：
Skulachev, VP
中科院分区：
文献类型：
--
作者：
Goglia, F;Skulachev, VP
假设线粒体解偶联蛋白作为脂肪酸过氧化阴离子的载体。这被认为是在膜电位（线粒体内部负）的驱动下，导致这些阴离子从线粒体内膜的内叶向外叶的电泳挤压。通过这种方式，内小叶中没有脂肪酸过氧化物，否则脂肪酸过氧化物会形成非常具有侵略性的氧化剂，破坏线粒体DNA、乌头碱酶和其他至关重要的线粒体基质局部成分。脂肪酸过氧化物的稳态浓度是很低的。这就解释了为什么少量的UCP2、3、4和5通常不足以对线粒体膜的H+电导做出大的贡献。-
It is hypothesized that mitochondrial uncoupling proteins operate as carriers of fatty acid peroxide anions. This is assumed to result in electrophoretic extrusion of such anions from the inner to the outer leaflet of the inner mitochondrial membrane, being driven by membrane potential ( mitochondrial interior negative). In this way, the inner leaflet is ridded of fatty acid peroxides that otherwise can form very aggressive oxidants damaging mitochondrial DNA, aconitase, and other mitochondrial matrix-localized components of vital importance. The steady-state concentration the fatty acid peroxides is known to be low. This explains why UCP2, 3, 4, and 5 are present in small amounts usually insufficient to make a large contribution to the H+ conductance of the mitochondrial membrane. -