Phenotypic and genetic parameters of antibody and delayed-type hypersensitivity responses of lactating Holstein cows
Phenotypic and genetic parameters of antibody and delayed-type hypersensitivity responses of lactating Holstein cows
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DOI：
10.1016/j.vetimm.2013.03.014
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发表时间：
2013-08-15
影响因子：
1.8
通讯作者：
Mallard, Bonnie A.
中科院分区：
文献类型：
--
作者：
Heriazon, Armando;Quinton, Margaret;Mallard, Bonnie A.
利用不同的表型标记培育奶牛已被认为是改善健康和减少传染病的有害后果的可行途径。在猪身上进行的研究已经证明了抗体(AmIR)和细胞(CMIR)介导的免疫反应作为数量性状的价值，通过使用免疫反应(IR)性状的估计育种值(EBV)来选择家畜来提高免疫反应性。对牛的研究已经测试了使用IR特征作为表型标记来将奶牛分为高(HR)、中(AR)和低(LR)响应者的可能性。关于哺乳奶牛的AMIR和CMIR的遗传参数或它们与生产、构型、繁殖力或健康性状的表型和遗传关联的信息很少或无法获得。本研究的目的是评价AMIR和CMIR的表型和遗传参数作为数量免疫性状(n=6)，并与奶牛的生产、繁殖力和健康性状进行比较，以用于改善奶牛健康的选择指标。这项研究的结果显示出显著的AMIR和CMIR反应。大多数IR性状与产量、健康或育性性状的表型相关不显著。迟发型超敏反应(DTH)杀灭白色念珠菌全细胞(CAWC)的遗传力(h(2))在48h(0.54)和14d(0.42)最高。其中Amir 14与Amir 21的遗传相关最高(0.99)，DTH与CAWC的遗传相关最高(0.93)，DTH与CAWC的遗传相关最高(0.93)。AMIR与FAT%(0.18)和CMIR与蛋白质%(-0.15)之间存在两个重要且显著的父本EBV相关性。总而言之，这项研究表明，AMIR和CMIR都是牛的可遗传性状，可以考虑将它们纳入旨在改善健康的选择指数。(C)Elsevier B.V.出版的2013年
Breeding dairy cattle using diverse phenotypic markers has been suggested as a feasible approach to improve health and decrease the deleterious consequences of infectious diseases. Studies conducted in pigs have demonstrated the value of antibody (AMIR)- and cell (CMIR)-mediated immune responses as quantitative traits for improving immune responsiveness by selecting livestock using estimated breeding values (EBV) for immune response (IR) traits. Studies of cattle have tested the possibility of using IR traits as phenotypic markers to classify cows as high (HR), average (AR) and low (LR) responders. Information is scarce or unavailable about either genetic parameters of AMIR and CMIR or their phenotypic and genetic associations with production, conformation, fertility or health traits in lactating dairy cattle. The objectives of the current study were to evaluate phenotypic and genetic parameters of both AMIR and CMIR as quantitative immunological traits (n = 6) in comparison with production, fertility and health traits in dairy cattle for their use in a selection index intended to improve bovine health. Results of this study showed significant AMIR and CMIR responses. Most phenotypic correlations between IR traits and production, health or fertility traits were not significant. The highest heritabilities (h(2)) were observed for delayed-type hypersensitivity (DTH) to killed Candida albicans whole cell (CaWC) at 48 h (0.54) and AMIR day 14 (0.42). The highest genetic correlations were observed between AMIR 14 and AMIR 21 (0.99) and between DTH to CaWC 24 h and DTH to CaWC 48 h (0.93). Two important and significant sire EBV correlations were noted between AMIR and fat % (0.18), and between CMIR and protein % (-0.15). In conclusion, this study demonstrated that both AMIR and CMIR are heritable traits in cattle and could be considered for their inclusion in a selection index intended to improve health. (C) 2013 Published by Elsevier B.V.