P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila
P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila
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DOI：
10.7554/elife.11346
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发表时间：
2015-12-29
期刊：
影响因子：
7.7
通讯作者：
Anderson, David J.
中科院分区：
文献类型：
--
作者：
Hoopfer, Eric D.;Jung, Yonil;Anderson, David J.
大脑是如何产生攻击性行为的，以及攻击性回路是如何与那些调解求爱的回路相关联的，都还没有得到很好的理解。在果蝇中进行的一项大规模的攻击促进神经元筛选中，发现了几个独立的命中，这些命中增强了雄性间的攻击和求偶。基因交叉显示，8-10个P1中间神经元，以前被认为是专门控制男性求爱，足以促进战斗。光遗传学实验表明，P1激活可以促进侵略的阈值低于所需的翅膀延伸。在没有翅膀伸展的情况下，P1的激活通过一种可以持续几分钟的内部状态触发了持续的攻击。高频P1激活促进翼的延伸和抑制侵略在光刺激，而侵略恢复和翼的延伸抑制以下光刺激偏移。因此，P1神经元激活促进了一种潜在的、内部的状态，这种状态促进了攻击和求爱，并以一种阈值依赖的、反向的方式控制着这些社会行为的公开表达。
How brains are hardwired to produce aggressive behavior, and how aggression circuits are related to those that mediate courtship, is not well understood. A large-scale screen for aggression-promoting neurons in Drosophila identified several independent hits that enhanced both inter-male aggression and courtship. Genetic intersections revealed that 8-10 P1 interneurons, previously thought to exclusively control male courtship, were sufficient to promote fighting. Optogenetic experiments indicated that P1 activation could promote aggression at a threshold below that required for wing extension. P1 activation in the absence of wing extension triggered persistent aggression via an internal state that could endure for minutes. High-frequency P1 activation promoted wing extension and suppressed aggression during photostimulation, whereas aggression resumed and wing extension was inhibited following photostimulation offset. Thus, P1 neuron activation promotes a latent, internal state that facilitates aggression and courtship, and controls the overt expression of these social behaviors in a threshold-dependent, inverse manner.