MicroRNA sequence polymorphisms and the risk of different types of cancer.
MicroRNA sequence polymorphisms and the risk of different types of cancer.
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DOI：
10.1038/srep03648
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发表时间：
2014-01-13
影响因子：
4.6
通讯作者：
Fang JY
中科院分区：
文献类型：
--
作者：
Hu Y;Yu CY;Wang JL;Guan J;Chen HY;Fang JY
MicroRNAs （miRNAs）参与多种生物学途径，可能作为致癌基因或肿瘤抑制因子。miRNA中的单核苷酸多态性（snp） （mirsnp）可能通过影响miRNA功能和/或成熟来促进癌变；然而，报道的mirsnp与癌症风险之间的关系仍然不一致。在这里，我们使用大规模病例对照研究的数据调查了9种常见的mirsnp与癌症风险之间的关系。研究人员分析了8个前体mirna (pre-miRNA) SNP （rs2043556/miR-605、rs3746444/miR-499a/b、rs4919510/miR-608、rs2910164/miR-146a、rs11614913/miR-196a2、rs895819/miR-27a、rs2292832/miR-149、rs6505162/miR-423）和1个primary-miRNA (pri-miRNA) SNP (rs1834306/miR-100)，这些SNP来自于8种常见癌症的7项已发表研究中的16399例病例和21779例对照。交叉表型荟萃分析（CPMA）显示，rs2910164 C （P = 1.11E-03）、rs2043556 C （P = 0.0165）、rs6505162 C （P = 2.05E-03）和rs895819 （P = 0.0284）与癌症总体风险显著相关。总之，mirsnp可能会影响个体对各种癌症的易感性。
MicroRNAs (miRNAs) participate in diverse biological pathways and may act as oncogenes or tumor suppressors. Single nucleotide polymorphisms (SNPs) in miRNAs (MirSNPs) might promote carcinogenesis by affecting miRNA function and/or maturation; however, the association between MirSNPs reported and cancer risk remain inconsistent. Here, we investigated the association between nine common MirSNPs and cancer risk using data from large scale case-control studies. Eight precursor-miRNA (pre-miRNA) SNPs (rs2043556/miR-605, rs3746444/miR-499a/b, rs4919510/miR-608, rs2910164/miR-146a, rs11614913/miR-196a2, rs895819/miR-27a, rs2292832/miR-149, rs6505162/miR-423) and one primary-miRNA (pri-miRNA) SNP (rs1834306/miR-100) were analyzed in 16399 cases and 21779 controls from seven published studies in eight common cancers. With a novel statistic, Cross phenotype meta-analysis (CPMA) of the association of MirSNPs with multiple phenotypes indicated rs2910164 C (P = 1.11E-03), rs2043556 C (P = 0.0165), rs6505162 C (P = 2.05E-03) and rs895819 (P = 0.0284) were associated with a significant overall risk of cancer. In conclusion, MirSNPs might affect an individual's susceptibility to various types of cancer.