SPONTANEOUS MAMMARY ADENOCARCINOMAS IN TRANSGENIC MICE THAT CARRY AND EXPRESS MTV/MYC FUSION GENES
SPONTANEOUS MAMMARY ADENOCARCINOMAS IN TRANSGENIC MICE THAT CARRY AND EXPRESS MTV/MYC FUSION GENES
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DOI：
10.1016/0092-8674(84)90257-5
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发表时间：
1984-01-01
期刊：
影响因子：
64.5
通讯作者：
LEDER, P
中科院分区：
文献类型：
--
作者：
STEWART, TA;PATTENGALE, PK;LEDER, P
共产生了13种转基因小鼠，它们携带正常的小鼠myc基因，其中myc启动子区域的越来越大部分已被激素诱导的小鼠乳腺肿瘤病毒[MTV]启动子取代。尽管融合基因在这些动物中的表达有所不同，但其中两个转基因菌株的女性创始人在其中一次怀孕早期自发地患上了乳房腺癌。这些创始动物的肿瘤和乳房组织都表达了与融合基因相对应的RNA转录本。在研究最好的品系中，所有可获得的遗传了MTV/myc基因的F1雌性后代在第二次或第三次怀孕期间也患上了乳腺癌。虽然它对这些小鼠的早期发育没有明显的影响，但宪法上解除管制的myc基因似乎是一种可遗传的易感因素，有利于加速组织特异性腺癌的发展。
Thirteen strains of transgenic mice were produced that carry an otherwise normal mouse myc gene in which increasingly larger portions of the myc promoter region have been replaced by a hormonally inducible mouse mammary tumor virus [MTV] promoter. Although expression of the fusion genes varies among these animals, the female founders of 2 of these transgenic strains spontaneously developed mammary adenocarcinomas during one of their early pregnancies. Both the tumors and the breast tissue of these founder animals expressed RNA transcripts corresponding to the fusion gene. In the best studied strain, all the available F1 female progeny that inherited the MTV/myc gene also developed mammary adenocarcinomas during their 2nd or 3rd pregnancies. Although it has no obvious effect on the early development of these mice, the constitutionally deregulated myc gene appears to act as a heritable, predisposing factor favoring the accelerated development of a tissue-specific adenocarcinoma.