High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection
High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection
复制标题
肿瘤浸润巨噬细胞密度高预示原发性肝细胞癌切除后预后不良
DOI：
10.1016/j.humpath.2008.08.011
复制
发表时间：
2009-03-01
期刊：
影响因子：
3.3
通讯作者：
Zheng, Limin
中科院分区：
文献类型：
--
作者：
Ding, Tong;Xu, Jing;Zheng, Limin
巨噬细胞构成肿瘤白细胞浸润的主要成分，并在不同的肿瘤微环境中发挥不同的作用。本研究应用免疫组织化学方法检测了137例肝癌组织中CD 68（+）巨噬细胞的分布，并对巨噬细胞在肝癌切除术后的分布进行了观察，旨在探讨巨噬细胞在肝癌切除术后的预后价值。通过Kaplan-Meier分析和考克斯回归分析评价瘤内、边缘和瘤周巨噬细胞密度的预后价值。肿瘤内和边缘巨噬细胞密度与总生存率（分别为P = 0.034和0.004）和无病生存率（分别为P = 0.006和0.009）呈负相关。相反，肿瘤周围巨噬细胞密度与总生存期和无病生存期均无关。肿瘤内巨噬细胞密度是总生存期（风险比= 1.721，P = 0.049）和无病生存期（风险比= 2.165，P = 0.007）的独立预测因子。边缘巨噬细胞密度，而不是肿瘤内巨噬细胞密度，与血管浸润，肿瘤多样性，和纤维囊形成。我们的研究结果表明，高巨噬细胞浸润预测肝癌患者预后不良。这些结果，连同我们先前的报告显示肿瘤组织不同区域中巨噬细胞的不同激活模式，意味着这些区域中的巨噬细胞可能使用不同的策略来促进肿瘤进展。(c)2009 Elsevier Inc. All rights reserved.
Macrophages constitute a major component of the leukocyte infiltrate of tumors and perform distinct roles in different tumor microenvironments. This study attempted to investigate the prognostic values of tumor-infiltrating macrophages in patients with hepatocellular carcinoma after resection, paying particular attention to their tissue microlocalization, The CD68(+) macrophages were assessed by immunohistochemistry in tissues from 137 patients with hepatocellular carcinoma. Prognostic value of intratumoral, marginal, and peritumoral macrophage densities was evaluated by Kaplan-Meier analysis and Cox regression. Both intratumoral and marginal macrophage densities were associated inversely with overall survival (P = .034 and .004, respectively) and disease-free survival (P = .006 and .009, respectively). In contrast, peritumoral macrophage density was associated with neither overall survival nor disease-free survival. Intratumoral macrophage density emerged as an independent prognosticator of overall survival (hazard ratio - 1.721, P - .049) and disease-free survival (hazard ratio = 2.165, P = .007). Marginal macrophage density, but not intratumoral macrophage density, was associated with vascular invasion, tumor multiplicity, and fibrous capsule formation. Our results demonstrate that high macrophage infiltration predicts poor prognosis in patients with hepatocellular carcinoma. These results, together With Our previous report showing the distinct activation patterns of macrophages in different areas of tumor tissue, implies that macrophages in those areas may use different strategies to promote the tumor progression. (c) 2009 Elsevier Inc. All rights reserved.