Extended preservation of human liver grafts with UW solution.
Extended preservation of human liver grafts with UW solution.
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DOI：
10.1001/jama.1989.03420050061039
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发表时间：
1989-02
期刊：
影响因子：
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通讯作者：
S. Todo;Jose Nery;Katsuhiko Yanaga;L. Podesta;Robert D. Gordon;T. Starzl
中科院分区：
文献类型：
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作者：
S. Todo;Jose Nery;Katsuhiko Yanaga;L. Podesta;Robert D. Gordon;T. Starzl
对用威斯康星大学(UW)液保存4~2 4h的185例同种异体肝与用常规Euro-Collins液保存3~9 1/2h的180例同种异体肝的存活率进行比较。虽然UW保存的肝脏的平均保存时间几乎是Euro-Collins保存的肝脏的两倍，但UW保存的移植物存活率更高，允许同等的患者存活，并且原发无功能的比率更低，再次移植的需要减少，肝动脉血栓发生率更低。UW保存24小时的移植物保存时间与术后第一周的肝功能异常无相关性。相比之下，用Euro-Collins溶液保存超过5小时的肝脏显著增加了肝功能测试的扰动。本文描述了UW溶液对肝移植的潜在革命性影响。
The fate of 185 cadaveric liver homografts preserved for four to 24 hours with University of Wisconsin (UW) solution was compared with that of 180 grafts preserved for three to 9 1/2 hours with conventional Euro-Collins solution. Although the average preservation time of the UW-preserved livers was almost twice as long as that of the Euro-Collins-preserved livers, the UW-preserved grafts survived at a higher rate; permitted equal patient survival; and had a lower rate of primary nonfunction, a reduced need for retransplantation, and a lower rate of hepatic artery thrombosis. There was no correlation between the time of preservation of UW-preserved grafts up to 24 hours and liver function abnormalities in the first postoperative week. In contrast, livers preserved with Euro-Collins solution for more than five hours had significantly increased perturbations of hepatic function tests. The potential revolutionary effect of the UW solution on liver transplantation is described herein.