Protein kinase B/Akt regulation in diabetic kidney disease.
Protein kinase B/Akt regulation in diabetic kidney disease.
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DOI：
10.2741/s135
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Brazil, Derek P
中科院分区：
文献类型：
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作者：
Heljic, Mediha;Brazil, Derek P
关于蛋白激酶 B/Akt 已有许多评论，重点关注其历史，可以追溯到 1977 年 Staal 分离出 Akt8 转化鼠白血病病毒，到 1991 年三个小组共同发现 Akt1 基因（第 7 篇评论）。目前 PubMed 数据库中有超过 22,000 篇以“Akt”为关键词的出版物 - 这些出版物描述了有关 Akt 同工型生理功能的大量不同数据。其中许多出版物描述了 Akt 的作用，从其对细胞过程（如葡萄糖摄取、细胞存活和血管生成）的需求，到在癌症和缺血等疾病中的作用 (22)。本综述将重点关注糖尿病或糖尿病肾病 (DN) 期间不同肾细胞中 Akt 信号传导的证据。
Many reviews have been written on protein kinase B/Akt focusing on its history dating back from the isolation of the Akt8 transforming murine leukemia virus by Staal in 1977, to the co-discovery of the Akt1 gene by the three groups in 1991 (reviewed in 7). There are currently over 22,000 publications in the PubMed database with "Akt" as a keyword - these publications describe a wealth of diverse data on the physiological functions of Akt isoforms. Many of these publications describe roles of Akt ranging from its requirement for cellular processes such as glucose uptake, cell survival and angiogenesis to roles in diseases such as cancer and ischaemia (22). This review will focus on the evidence for Akt signaling in different kidney cells during diabetes, or diabetic nephropathy (DN).