Factors associated with symptoms of anxiety and depression in five cohorts of community-based older people: the HALCyon (Healthy Ageing across the Life Course) Programme
Factors associated with symptoms of anxiety and depression in five cohorts of community-based older people: the HALCyon (Healthy Ageing across the Life Course) Programme
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DOI：
10.1017/s0033291711000195
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发表时间：
2011-10-01
影响因子：
6.9
通讯作者：
Deary, I. J.
中科院分区：
文献类型：
--
作者：
Gale, C. R.;Sayer, A. Aihie;Deary, I. J.
背景资料。焦虑和抑郁症状在老年人中很常见，但早期和晚期影响风险的因素的相对重要性尚不清楚，特别是在焦虑的情况下。我们使用了生命历程健康老龄化(Halcyon)合作研究计划中的五个队列的数据：1936年阿伯丁出生队列、凯菲利前瞻性研究、赫特福德郡老龄化研究、赫特福德郡队列研究和1921年洛锡安出生队列。我们使用Logistic回归分析早期和晚期生活因素与焦虑或抑郁风险的关系，并进行Meta分析以获得每个因素的总体效果。在横断面分析中，神经质更强、认知或身体功能更差、残疾更大、服用更多药物与焦虑或抑郁的总体可能性增加相关。无论是在童年时期还是现在，较低的社会阶层、心脏病、中风或糖尿病病史与焦虑或抑郁风险增加之间的关联都减弱了，在调整了潜在的混杂或中介变量后，这种关联在统计上不再显著。出生体重与晚年生活中的焦虑或抑郁没有关联。晚年的焦虑和抑郁都与个性、认知和身体功能、残疾和健康状况密切相关，这些都是同时测量的。本文还讨论了这些关联可能存在的可能机制。
Background. Symptoms of anxiety and depression are common in older people, but the relative importance of factors operating in early and later life in influencing risk is unclear, particularly in the case of anxiety.Method. We used data from five cohorts in the Healthy Ageing across the Life Course (HALCyon) collaborative research programme: the Aberdeen Birth Cohort 1936, the Caerphilly Prospective Study, the Hertfordshire Ageing Study, the Hertfordshire Cohort Study and the Lothian Birth Cohort 1921. We used logistic regression to examine the relationship between factors from early and later life and risk of anxiety or depression, defined as scores of 8 or more on the subscales of the Hospital Anxiety and Depression Scale, and meta-analysis to obtain an overall estimate of the effect of each.Results. Greater neuroticism, poorer cognitive or physical function, greater disability and taking more medications were associated in cross-sectional analyses with an increased overall likelihood of anxiety or depression. Associations between lower social class, either in childhood or currently, history of heart disease, stroke or diabetes and increased risk of anxiety or depression were attenuated and no longer statistically significant after adjustment for potential confounding or mediating variables. There was no association between birth weight and anxiety or depression in later life.Conclusions. Anxiety and depression in later life are both strongly linked to personality, cognitive and physical function, disability and state of health, measured concurrently. Possible mechanisms that might underlie these associations are discussed.