Integrin traffic - the update.
Integrin traffic - the update.
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DOI：
10.1242/jcs.161653
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发表时间：
2015-03-01
影响因子：
4
通讯作者：
Ivaska J
中科院分区：
文献类型：
--
作者：
De Franceschi N;Hamidi H;Alanko J;Sahgal P;Ivaska J
整合素是一类跨膜细胞表面分子，构成细胞外基质(ECM)的主要黏附受体，对多细胞生物体的存在是不可或缺的。在脊椎动物中，存在24种不同的整合素异源二聚体，具有不同的底物特异性和组织表达。整合素-细胞外-配体的相互作用为细胞提供了一个物理锚，并触发了一系列决定细胞命运的细胞内信号事件。在细胞迁移、侵袭和胞质分裂等过程中，通过整合素受体的胞内和胞外快速转运，黏附的动态重塑是细胞调节整合素-细胞外基质相互作用从而调节细胞信号转导的重要机制。整合素流量作为一种在细胞内转移黏附受体的手段的最初概念现在已经扩展，因为越来越多的人意识到流量与细胞信号装置密切相关。此外，内体途径正在成为整合素在细胞中稳定和表达的关键调节因素。因此，整合素的运输与许多病理情况有关，特别是在癌症中。大约十年前，我们在《细胞科学杂志》上发表了一篇题为《整合素流量》的评论文章。随着该领域的进步，我们认为向越来越多对整合素交通感兴趣的研究人员提供最新情况是合适的。
Integrins are a family of transmembrane cell surface molecules that constitute the principal adhesion receptors for the extracellular matrix (ECM) and are indispensable for the existence of multicellular organisms. In vertebrates, 24 different integrin heterodimers exist with differing substrate specificity and tissue expression. Integrin–extracellular-ligand interaction provides a physical anchor for the cell and triggers a vast array of intracellular signalling events that determine cell fate. Dynamic remodelling of adhesions, through rapid endocytic and exocytic trafficking of integrin receptors, is an important mechanism employed by cells to regulate integrin–ECM interactions, and thus cellular signalling, during processes such as cell migration, invasion and cytokinesis. The initial concept of integrin traffic as a means to translocate adhesion receptors within the cell has now been expanded with the growing appreciation that traffic is intimately linked to the cell signalling apparatus. Furthermore, endosomal pathways are emerging as crucial regulators of integrin stability and expression in cells. Thus, integrin traffic is relevant in a number of pathological conditions, especially in cancer. Nearly a decade ago we wrote a Commentary in Journal of Cell Science entitled ‘Integrin traffic’. With the advances in the field, we felt it would be appropriate to provide the growing number of researchers interested in integrin traffic with an update.
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DOI：
10.1111/j.1600-0854.2012.01327.x
发表时间：
2012-04
期刊：
Traffic (Copenhagen, Denmark)
影响因子：
--
作者：
Arjonen A;Alanko J;Veltel S;Ivaska J
通讯作者：
Ivaska J
影响因子：
4
作者：
Bridgewater, Rebecca E.;Norman, Jim C.;Caswell, Patrick T.
通讯作者：
Caswell, Patrick T.
DOI：
10.1186/bcr2232
发表时间：
2009
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Eiseler T;Döppler H;Yan IK;Goodison S;Storz P
通讯作者：
Storz P
影响因子：
11.8
作者：
Christoforides, Claudine;Rainero, Elena;Brown, Kristin K.;Norman, Jim C.;Toker, Alex
通讯作者：
Toker, Alex
ACAP1 蛋白调节货物结合的机制见解
影响因子：
4.8
作者：
Bai, Ming;Pang, Xiaoyun;Hsu, Victor W.
通讯作者：
Hsu, Victor W.