MAGNITUDE OF BODY-CEL-MASS DEPLETION AND THE TIMING OF DEATH FROM WASTING IN AIDS
MAGNITUDE OF BODY-CEL-MASS DEPLETION AND THE TIMING OF DEATH FROM WASTING IN AIDS
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DOI：
10.1093/ajcn/50.3.444
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发表时间：
1989-09-01
影响因子：
7.1
通讯作者：
PIERSON, RN
中科院分区：
文献类型：
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作者：
KOTLER, DP;TIERNEY, AR;PIERSON, RN
营养不良对艾滋病患者生存的影响是通过检测身体细胞团消耗的大小作为死亡时间的函数来评估的。体细胞质量估计为全身钾含量，由全身计数确定。随着患者濒临死亡，体细胞团逐渐枯竭。死亡时体细胞质量的外推值和观测值是正常值的54%。体重与死亡的关系相似，预计死亡时的体重为理想体重的66%。我们的结论是，艾滋病造成的死亡与组织消耗的程度有关，与消耗的根本原因无关。在这项研究中看到的消瘦程度类似于历史上报道的半停滞，有或没有相关的感染。这一观察表明，成功地保持身体质量可以延长艾滋病患者的生存时间。
The impact of malnutrition on survival in AIDS was evaluated by examining the magnitude of body-cell-mass depletion as a function of time from death. Body cell mass estimated as total body-potassium content and determined by whole-body counting. There was progressive depletion of body cell mass as patients neared death. The extrapolated and observed values for body cell mass at death were 54% of normal. Body weight had a similar relationship to death, with a projected body weight at death of 66% of ideal. We conclude that death from wasting in AIDS is related to the magnitude of tissue depletion and is independent of the underlying cause of wasting. The degree of wasting seen in this study is similar to historical reports of semistarvation, with or without associated infections. This observation suggests that successful attempts to maintain body mass could prolong survival in patients with AIDS.