The relationship between extrapyramidal signs and cognitive function in patients with moderate to severe Alzheimer's disease
The relationship between extrapyramidal signs and cognitive function in patients with moderate to severe Alzheimer's disease
复制标题
中重度阿尔茨海默病患者锥体外系体征与认知功能的关系
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
R. Lévy
中科院分区：
文献类型：
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作者：
M. Richards;D. McLoughlin;R. Lévy
我们研究了 137 名居住在英国伦敦内城区特定区域的中度至重度阿尔茨海默病 (AD) 患者的锥体外系体征 (EPS) 与神经心理学表现之间的关联。 AD 中 EPS 的存在与独特的神经心理学特征相关，提示额纹状体变性的累加效应。然而，有和没有 EPS 的患者之间的功能能力没有显着差异。这些发现支持这样的假设：EPS 代表了叠加在 AD 经典特征上的平行独立病理学，而不是提供整体 AD 严重程度的标记。
We studied the association between extrapyramidal signs (EPS) and neuropsychological performance in 137 patients with moderate to severe Alzheimer's disease (AD) residing in a geographically defined area of inner London, UK. The presence of EPS in AD was associated with a distinct neuropsychological profile, suggestive of the additive effect of frontostriatal degeneration. Yet, there was no significant difference in functional capacity between patients with and without EPS. These findings support the hypothesis that EPS represent a parallel independent pathology superimposed over the classical features of AD, rather than providing a marker for global AD severity.