Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers
Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers
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DOI：
10.1002/ppul.20403
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发表时间：
2006-06-01
影响因子：
3.1
通讯作者：
Tepper, Robert S.
中科院分区：
文献类型：
--
作者：
Castillo, Andres;Llapur, Conrado J.;Tepper, Robert S.
我们描述了一种测量睡眠婴儿一氧化碳扩散能力（DLCO）和肺泡容积（V-A）的方法，使用单次4秒屏气技术。屏气动作是通过诱导呼吸系统的呼吸暂停而获得的。在气道压力为30cmh (2)O （V-30）的情况下，用室内空气对肺容量进行多次充气，可抑制吸气力。然后用含有氦气和稳定的一氧化碳同位素（(CO)-O-18）的测试气体对呼吸系统进行充气，呼吸暂停维持4秒，然后被动呼气至功能剩余容量。用质谱仪连续测量氦和(CO)-O-18的浓度。对12名6-22个月大的健康婴儿进行了评估。在12名受试者中，有9名在30cmh (2)O （V-A30）和DLCO的重复测量值在10%以内，这是年龄较大的儿童和成人的推荐值。9名受试者VA30和DLCO值随体长的增加而增加（r(2)分别为0.82和0.79）。其余3名受试者有2个值在10-15%之间。在肺容量升高时，单次屏气技术测量V-A和DLCO提供了评估生命早期肺实质生长发育的潜力。
We describe a method for measuring carbon monoxide diffusing capacity (DLCO) and alveolar volume (V-A) in sleeping infants, using a single 4-sec breath-hold technique. The breath-hold maneuver is obtained by inducing a respiratory pause of the respiratory system. Several inflations of the respiratory system with room air to a lung volume with an airway pressure of 30 cmH(2)O (V-30) inhibit inspiratory effort. The respiratory system is then inflated with a test gas containing helium and a stable isotope of carbon monoxide ((CO)-O-18), and a respiratory pause is maintained for 4 sec and followed by passive expiration to functional residual capacity. Concentrations of helium and (CO)-O-18 are continuously measured with a mass spectrometer. Twelve healthy infants between 6-22 months of age were evaluated. For 9 of 12 subjects, duplicate measurements of alveolar volume at 30 cmH(2)O (V-A30) and DLCO were within 10%, which are the recommendations for older children and adults. Among these 9 subjects, values of VA30 and DLCO increased with increasing body length (r(2) = 0.82 and 0.79, respectively). The remaining 3 subjects had two values within 10-15%. Measurement of V-A and DLCO with the single breath-hold technique at an elevated lung volume offers the potential to assess growth and development of the lung parenchyma early in life.