Transcriptome of rat subcortical white matter and spinal cord after spinal injury and cortical stimulation.
Transcriptome of rat subcortical white matter and spinal cord after spinal injury and cortical stimulation.
复制标题
脊髓损伤和皮质刺激后大鼠皮质下白质和脊髓的转录组。
DOI：
10.1038/s41597-021-00953-4
复制
发表时间：
2021-07-15
期刊：
影响因子：
9.8
通讯作者：
Perlmutter SI
中科院分区：
文献类型：
--
作者：
Kondiles BR;Wei H;Chaboub LS;Horner PJ;Wu JQ;Perlmutter SI
脊髓损伤破坏了上行和下行神经信号，导致感觉和运动功能障碍。在临床和研究环境中使用电刺激神经调节来诱导神经可塑性并改善脊柱创伤后的功能恢复。然而，电刺激影响恢复的机制仍不清楚。在这项研究中，我们研究了损伤后皮层电刺激对中枢神经系统几个水平转录的影响。我们进行了一个单侧，不完全性颈椎挫伤大鼠和交付一个星期的刺激对侧运动皮层激活皮质脊髓束和其他途径。从双侧皮质下白色物质和3个脊髓水平中纯化RNA。在这里，我们提供了完整的数据集，希望它将是有用的研究人员研究电刺激作为一种治疗，以改善恢复与脊髓损伤相关的缺陷。描述报告数据的机器可访问元数据文件：10.6084/m9.figshare.14129012
Spinal cord injury disrupts ascending and descending neural signals causing sensory and motor dysfunction. Neuromodulation with electrical stimulation is used in both clinical and research settings to induce neural plasticity and improve functional recovery following spinal trauma. However, the mechanisms by which electrical stimulation affects recovery remain unclear. In this study we examined the effects of cortical electrical stimulation following injury on transcription at several levels of the central nervous system. We performed a unilateral, incomplete cervical spinal contusion injury in rats and delivered stimulation for one week to the contralesional motor cortex to activate the corticospinal tract and other pathways. RNA was purified from bilateral subcortical white matter and 3 levels of the spinal cord. Here we provide the complete data set in the hope that it will be useful for researchers studying electrical stimulation as a therapy to improve recovery from the deficits associated with spinal cord injury. Machine-accessible metadata file describing the reported data: 10.6084/m9.figshare.14129012