Serologically Verified Human Bocavirus Pneumonia in Children
Serologically Verified Human Bocavirus Pneumonia in Children
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DOI：
10.1002/ppul.21151
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发表时间：
2010-02-01
影响因子：
3.1
通讯作者：
Korppi, Matti
中科院分区：
文献类型：
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作者：
Don, Massimiliano;Soderlund-Venermo, Maria;Korppi, Matti
工作假设：人类博卡病毒（HBoV）是一种新发现的细小病毒，常见于患有急性呼吸道和肠道感染的儿童中。本研究的目的是通过使用新开发的抗体检测来评估 HBoV 在儿科社区获得性肺炎 (CAP) 中的作用以及意大利北部儿童前瞻性研究中 HBoV 血清阳性率。材料/患者和方法：在为期 15 个月的研究期间，124 名儿童因疑似肺炎入院，其中 101 名儿童经放射学确诊为肺炎。通过对 16 种微生物进行抗体检测，包括新开发的 HBoV 酶联免疫分析，研究了 CAP 的病因。 结果：12 名儿童（12%）发现急性 HBoV 感染的血清学证据，其中 7 例为单一感染，5 例为混合感染（4 例为其他病毒，3 例为细菌）。 IgM阳性11例。在 6 个病例中观察到配对血清之间 IgG 抗体出现诊断性升高。 HBoV 是仅次于呼吸道合胞病毒（117%）的第二常见病毒。 HBoV 血清阳性率随着年龄的增长而增加，学龄前几乎达到 100%。结论：目前的结果表明，HBoV 能够诱导显着的抗体反应，并表明 HBoV 可能是儿童肺炎的相当常见的原因。大多数儿童血清转化为 HBoV 发生在幼儿期。小儿肺科。 2010；45：120-126。 (C) 2009 Wiley-Liss, Inc.
Working Hypothesis: Human bocavirus (HBoV) is a newly identified parvovirus frequently found in children suffering from acute respiratory and intestinal infections. The aim of the present study was to evaluate, by using a newly developed antibody assay, the role of HBoV in pediatric community-acquired pneumonia (CAP) and the seropositivity rate to HBoV in a prospective study in North-Italian children. Materials/Patients and Methods: During a 15-month study period, 124 children were admitted due to presumptive pneumonia, and in 101 of them, pneumonia was radiologically confirmed. The etiology of CAP was studied by antibody assays to 16 microbes, including the newly developed enzyme immunoassay for HBoV Results: Serological evidence of acute HBoV infection was found in 12 (12%) children, being single in 7 and mixed in 5 cases (4 with other viruses and 3 with bacteria). IgM was positive in 11 cases. A diagnostic rise in IgG antibodies between paired sera was observed in six cases. HBoV was the second most common virus next to respiratory syncytial virus (117%). The seropositivity rate to HBoV increased with age, reaching nearly 100% before school age. Conclusions: The present results show that HBoV is able to induce significant antibody responses and suggest that HBoV may be a fairly common cause of pneumonia in children. Seroconversion to HBoV in most children takes place in early childhood. Pediatr Pulmonol. 2010;45:120-126. (C) 2009 Wiley-Liss, Inc.