Changes in hepatitis B virus DNA levels with acute HIV infection.
Changes in hepatitis B virus DNA levels with acute HIV infection.
复制标题
急性 HIV 感染时乙型肝炎病毒 DNA 水平的变化。
DOI：
10.1086/382534
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Thomas,DavidL
中科院分区：
文献类型：
--
作者：
Thio,ChloeL;Netski,DaleM;Myung,Jane;Seaberg,EricC;Thomas,DavidL
我们假设，急性感染人类免疫缺陷病毒（HIV）会削弱慢性B型肝炎（CH B）的免疫调节，导致血液中更高的B型肝炎病毒（HBV）DNA水平。为了验证这一假设，我们评估了连续的HBV DNA水平储存血清样本获得9名男子慢性乙型肝炎谁获得艾滋病毒感染。三种模式的变化，HBV DNA水平的HIV血清转换后指出。1例患者出现预期的HBV DNA升高，3例患者HBV DNA水平稳定，5例患者的HBV DNA水平意外平均降低6.29 log 10拷贝/mL，4例患者的B e抗原检测不到。急性HIV感染并不总是与血液HBV DNA水平升高相关。需要进一步的研究来了解与急性HIV感染相关的HBV DNA水平意外降低的机制。
We hypothesized that acute infection with human immunodeficiency virus (HIV) would diminish immunoregulation of chronic hepatitis B (CHB), resulting in higher blood hepatitis B virus (HBV) DNA levels. To test this hypothesis, we evaluated sequential HBV DNA levels in stored serum samples obtained from 9 men with CHB who acquired HIV infection. Three patterns of changes in HBV DNA levels were noted after HIV seroconversion. One man experienced the expected increase in HBV DNA, 3 men had stable HBV DNA levels, and, unexpectedly, 5 men had a mean decrease of 6.29 log10copies/mL in the HBV DNA level, with hepatitis B e antigen no longer detectable in 4. Acute HIV infection is not consistently associated with an increased blood HBV DNA level. Additional research is needed to understand the mechanism for the unexpected reductions in HBV DNA levels associated with acute HIV infection.