Voltage-Responsive Vesicles Based on Orthogonal Assembly of Two Homopolymers
Voltage-Responsive Vesicles Based on Orthogonal Assembly of Two Homopolymers
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基于两种均聚物正交组装的电压响应囊泡
DOI：
10.1021/ja1027502
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发表时间：
2010-07-14
影响因子：
15
通讯作者：
Yin, Yingwu
中科院分区：
文献类型：
--
作者：
Yan, Qiang;Yuan, Jinying;Yin, Yingwu
两种末端修饰的均聚物，聚苯乙烯-β-环糊精（PS-beta-CD）和聚环氧乙烷-二茂铁（PEO-Fc），在水溶液中可以通过主客体间的相互作用正交组装成超分子二嵌段共聚物（PS-beta-CD/PEO-Fc）。这些组装体可以进一步形成超分子囊泡，并且它们的组装和拆卸行为可以通过中间超分子连接的可逆缔合和解离而被电压可逆地切换。囊泡具有前所未有的性质，其组装或分解速度可以通过施加的电压强度来控制。发光光谱表明，囊泡作为纳米胶囊携带分子在其中空腔和外部电压强度准确地调节药物释放时间。
Two end-decorated homopolymers, poly(styrene)-beta-cyclodextrin (PS-beta-CD) and poly(ethylene oxide)-ferrocene (PEO-Fc), can orthogonally self-assemble into a supramolecular diblock copolymer (PS-beta-CD/PEO-Fc) in aqueous solutions based on the terminal host guest interactions. These assemblies can further form supramolecular vesicles, and their assembly and disassembly behaviors can be reversibly switched by voltage through the reversible association and disassociation of the middle supramolecular connection. The vesicles possess an unprecedented property that their assembly or disassembly speed can be controlled by the applied voltage strength. Luminescence spectroscopy demonstrates that the vesicles act as nanocapsules carrying molecules within their hollow cavities and that the external voltage strength accurately regulates the drug release time.