The use of C-reactive protein from cerebrospinal fluid for differentiating meningitis from other central nervous system diseases.
The use of C-reactive protein from cerebrospinal fluid for differentiating meningitis from other central nervous system diseases.
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使用脑脊液中的 C 反应蛋白来区分脑膜炎和其他中枢神经系统疾病。
DOI：
10.1093/infdis/151.5.854
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Mario J. Marcon
中科院分区：
文献类型：
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作者：
Jon S. Abramson;Kenneth D. Hampton;Sylvia Babu;Benedict L. Wasilanskas;Mario J. Marcon
采用胶乳玻片凝集试验对235例脑脊液进行C-反应蛋白(C-RP)测定。细菌性脑膜炎74例，病毒性脑膜炎10例，发热无细菌性脑膜炎80例，神经系统症状无感染25例，颅内出血10例，脑假瘤或脑积水继发颅内压增高16例，恶性肿瘤20例。第1组腰椎C-RP阳性率为97%(72/74)，第2~7组分别为0%(0/10)、6%(5/80)、20%(5/25)、50%(5/10)、6%(1/16)、30%(6/20)(P<0.0001)。C-RP检测细菌性脑膜炎的敏感性为97%(72/74)，特异性为86%(139/161)，阳性预测值为77%(72/94)，阴性预测值为99%(139/141)。这些数据表明，对脑脊液进行C-RP测定是排除患者细菌性脑膜炎的有用和快速的临床测试。
C-reactive protein (C-RP) determinations were performed by using the latex slide agglutination test on cerebrospinal fluid (CSF) from 235 patients. The patients were categorized into the following groups: bacterial meningitis (n = 74); viral meningitis (n = 10); fever without bacterial meningitis (n = 80); neurological symptoms without infection (n = 25); intracranial hemorrhage (n = 10); increased intracranial pressure that was secondary to pseudotumor cerebri or hydrocephalus (n = 16); and malignancies (n = 20). On the initial lumbar puncture, the C-RP was positive in 97% (72 of 74) of the patients in group 1, as compared with 0% (0 of 10), 6% (5 of 80), 20% (5 of 25), 50% (5 of 10), 6% (1 of 16), and 30% (6 of 20) in groups 2-7, respectively (P less than .0001). The C-RP test was able to detect bacterial meningitis with a sensitivity of 97% (72 of 74), a specificity of 86% (139 of 161), a positive predictive value of 77% (72 of 94), and a negative predictive value of 99% (139 of 141). These data indicate that C-RP determinations performed on CSF are useful and rapid clinical tests for the exclusion of the presence of bacterial meningitis in a patient.