Walking disability measures in multiple sclerosis patients: Correlations with MRI-derived global and microstructural damage
Walking disability measures in multiple sclerosis patients: Correlations with MRI-derived global and microstructural damage
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DOI：
10.1016/j.jns.2018.08.020
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发表时间：
2018-10-15
影响因子：
4.4
通讯作者：
Zivadinov, Robert
中科院分区：
文献类型：
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作者：
Jakimovski, Dejan;Weinstock-Guttman, Bianca;Zivadinov, Robert
背景：多发性硬化症(MS)患者的行走障碍与他们的宏观和微观MRI测量结果之间的关系仍不清楚。目的：探讨行走障碍与MRI所致病变、萎缩及微结构/轴突完整性的关系。方法：对71例MS患者进行临床检查，并进行扩展定时起立步行(ETGUG)和定时25英尺步行(T25FW)试验。此外，还进行了符号数字模式测试(SDMT)。计算标准化脑(NBV)、灰质(GMV)、白质(WMV)、皮质(CV)和深部GM(DGM)体积，以及病变体积(LV)和弥散张量成像(DTI)分数各向异性、平均扩散系数、径向扩散系数和轴向扩散系数的标量图。结果：T25FW和ETGUG与T2-LV(p<；.001)、全球(NBV，p<；.001)、组织特异性(GMV和CV，p<；.001)和地区性(DGM，p<；.001)相关。
Background: The relationship between walking disability in multiple sclerosis (MS) patients and their macro and microstructural MRI-derived measures still remains unclear. Objective: To assess the correlations between walking disability and MRI-derived lesion, atrophy, and micro-structural/axonal integrity outcomes.Methods: Seventy-one (71) MS patients were clinically examined, the expanded timed get-up and go (ETGUG), and timed 25-foot walk (T25FW) tests were assessed. Additionally, the Symbol Digit Modalities Test (SDMT) was obtained. Normalized brain (NBV), gray matter (GMV), white matter (WMV), cortex (CV), and deep GM (DGM) volumes, as well as lesion volumes (LV) and diffusion tensor imaging (DTI) scalar maps of fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity were calculated. Spearman correlation, partial correlation and stepwise regression analyses were performed.Results: T25FW and ETGUG were associated with T2-LV (p < .001), global (NBV, p < .001), tissue-specific (GMV and CV, p < .001) and regional (DGM p