Injectable Block Copolymer Hydrogels: Achievements and Future Challenges for Biomedical Applications
Injectable Block Copolymer Hydrogels: Achievements and Future Challenges for Biomedical Applications
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DOI：
10.1021/ma201261m
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发表时间：
2011-09-13
期刊：
影响因子：
5.5
通讯作者：
Lee, Doo Sung
中科院分区：
文献类型：
--
作者：
Cong Truc Huynh;Minh Khanh Nguyen;Lee, Doo Sung
在过去的二十年中，物理聚合物水凝胶已经被广泛地探索用于生物医学应用，例如药物递送和组织工程。这些水凝胶响应于Sol外部刺激（例如pH、温度、葡萄糖、电场、磁场、离子强度或它们的组合）而表现出溶胶-凝胶相变。水凝胶前体可以与生物活性分子或细胞混合，然后简单地注射到身体的特定部位。在新型水凝胶的开发和应用方面取得了实质性进展。在这个角度来看，我们报告的物理交联，响应pH值和/或温度的水凝胶及其药物和组织工程应用的最新进展。展望未来，包括注射水凝胶的剩余挑战，也进行了讨论。
In the past two decades, physical polymeric hydrogels have been extensively explored for biomedical applications, such as drug delivery and tissue engineering. These hydrogels exhibit a sol-gel phase transition in response to Sol external stimuli, such as pH, temperature, glucose, electric field, magnetic field, ionic strength, or their combination. Hydrogel precursors can be mixed with bioactive molecules or cells and then simply injected into the body at specific sites. Substantial progress has been made in the development of novel hydrogels and applications. In this Perspective, we report recent progress in physically cross-linked,hydrogels responding to pH and/or temperature and their pharmaceutical and tissue engineering applications. The outlook for the future, including remaining challenges of injectable hydrogels, is also discussed.