MicroRNA miR-7 Is Essential for Post-stroke Functional Recovery.
MicroRNA miR-7 Is Essential for Post-stroke Functional Recovery.
复制标题
DOI：
10.1007/s12975-021-00981-7
复制
发表时间：
2023-03
影响因子：
6.9
通讯作者：
Vemuganti, Raghu
中科院分区：
文献类型：
--
作者：
Mehta, Suresh L.;Chokkalla, Anil K.;Bathula, Saivenkateshkomal;Vemuganti, Raghu
Transient focal ischemia induces a sustained downregulation of miR-7 leading to derepression of its target α-synuclein (α-Syn), which promotes neuronal death. We previously showed that treatment with miR-7 mimic prevents α-Syn induction and protects brain after stroke in rodents irrespective of age and sex. To further decipher the role of miR-7, we currently studied infarction and motor function in miR-7 double knockout mice (lack both miR-7a and miR-7b) subjected to focal ischemia. Adult miR-7−/− mice showed similar motor and cognitive functions to miR-7+/+ mice. However, when subjected to even a mild focal ischemia, the miR-7−/− mice showed exacerbated brain damage and worsened motor function compared with the miR-7+/+ mice. Replenishing miR-7 in miR-7−/− mice (IV injection of miR-7 mimic) restored miR-7 mediated neuroprotection and motor recovery, potentially by preventing α-Syn protein induction. Thus, we show that miR-7 is an essential miRNA in the brain that prevents α-Syn translation and the ensuing brain damage after stroke.
登录
查看更多内容
影响因子：
7.3
作者：
Kim, TaeHee;Mehta, Suresh L.;Vemuganti, Raghu
通讯作者：
Vemuganti, Raghu
影响因子：
64.5
作者：
Kleaveland B;Shi CY;Stefano J;Bartel DP
通讯作者：
Bartel DP
DOI：
10.1038/jcbfm.2008.157
发表时间：
2009-04
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
通讯作者：
--
影响因子：
8.3
作者：
Morris-Blanco, Kahlilia C.;Kim, TaeHee;Vemuganti, Raghu
通讯作者：
Vemuganti, Raghu
影响因子：
6.3
作者：
Chelluboina, Bharath;Chokkalla, Anil K.;Vemuganti, Raghu
通讯作者：
Vemuganti, Raghu