Influenza-associated hospitalisation, vaccine uptake and socioeconomic deprivation in an English city region: an ecological study
Influenza-associated hospitalisation, vaccine uptake and socioeconomic deprivation in an English city region: an ecological study
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DOI：
10.1136/bmjopen-2018-023275
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发表时间：
2018-12-01
期刊：
影响因子：
2.9
通讯作者：
French, Neil
中科院分区：
文献类型：
--
作者：
Hungerford, Daniel;Ibarz-Pavon, Ana;French, Neil
目的每年，流感都给英国的国民健康服务体系带来沉重的负担。流感疫苗接种是预防严重疾病的有效措施，因此，最大限度地提高最脆弱人群的疫苗覆盖率是一个优先事项。我们的目的是确定社会经济状况与流感相关疾病（IAI）和流感疫苗覆盖率的相关程度。设计使用医院事件统计的回顾性观察研究。设置默西塞德郡，英格兰西北部，包括利物浦市。参与者默西塞德郡的居民在2004年4月至2016年3月期间因IAI住院，2014/2015年和2015年符合流感疫苗接种条件的默西塞德郡全科医生注册患者/2016年流感季节。暴露基于较低的超级输出区的社会经济剥夺。主要和次要结局指标发病率和风险结果默西塞德郡居民中有89058例与IAI相关的住院（平均年发病率=4.9/1000）。在15-39岁的成年人中，与最贫困的地区相比，社会经济最贫困的地区因IAI住院的频率更高（发病率比（IRR）2.08; 95%CI 1.76 - 2.45; p
Objectives Every year, influenza poses a significant burden on the National Health Service in England. Influenza vaccination is an effective measure to prevent severe disease, hence, maximising vaccine coverage in the most vulnerable is a priority. We aimed to identify the extent to which socioeconomic status is associated with influenza-associated illness (IAI) and influenza vaccine coverage.Design Retrospective observational study using hospital episode statistics.Setting Merseyside, North-West of England, including the city of Liverpool.Participants Residents of Merseyside hospitalised with IAI between April 2004 and March 2016, and Merseyside general practice registered patients eligible for influenza vaccination in 2014/2015 and 2015/2016 influenza seasons.Exposures Socioeconomic deprivation based on lower super output area English Indices of Deprivation scores.Primary and secondary outcome measures Incidence and risk of IAI hospitalisation, and vaccine uptake.Results There were 89 058 hospitalisations related to IAI among Merseyside residents (mean yearly rate=4.9 per 1000 population). Hospitalisations for IAI were more frequent in the most socioeconomically deprived areas compared with the least deprived in adults aged 15-39 years (incidence rate ratio (IRR) 2.08; 95% CI 1.76 to 2.45; p