Association of antiepileptic drug nonadherence with risk of seizures in adults with epilepsy
Association of antiepileptic drug nonadherence with risk of seizures in adults with epilepsy
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DOI：
10.1016/j.yebeh.2008.12.006
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发表时间：
2009-02-01
影响因子：
2.6
通讯作者：
Ettinger, Alan B.
中科院分区：
文献类型：
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作者：
Manjunath, Ranjani;Davis, Keith L.;Ettinger, Alan B.
本研究评估抗癫痫药物（AED）不依从性对后续癫痫发作风险的潜在影响。分析了来自美国的回顾性保险索赔。纳入标准为：年龄21-64岁，诊断为癫痫或非热性惊厥，>= 2张AED处方，>=启动AED前6个月，>=启动AED后60天加入保险。癫痫发作被定义为与癫痫或非热性惊厥相关的住院或急诊。观察开始于服药后第7天，以以下第一种情况结束：癫痫发作、保险退出或服药后365天。使用药物占有比（MPR）测量依从性，MPR = 1癫痫发作。有事件的患者平均随访时间为133天，无事件的患者平均随访时间为305天。未坚持服药者的癫痫发作风险比坚持服药者高21%（风险比= 1.205,P = 0.0002）。(C) 2008爱思唯尔公司版权所有。
This study evaluated the potential effect of antiepileptic drug (AED) nonadherence on the risk of subsequent seizure. Retrospective insurance claims from the United States were analyzed. Inclusion criteria were: age 21-64 years, diagnosis of epilepsy or nonfebrile convulsions, >= 2 AED prescriptions, and insurance enrollment for >= 6 months pre- and >= 60 days post-AED initiation. Seizure was defined as a hospital or emergency admission associated with epilepsy OF nonfebrile convulsions. Observation began 7 days post-drug initiation, ending with the first of the following: seizure, insurance disenrollment, or 365 days post-drug initiation. Adherence was measured using the medication possession ratio (MPR), with MPR = 1 seizure. Mean follow-up was 133 days among subjects with event and 305 days for patients without event. Seizure risk was 21% higher among nonadherers (hazard ratio = 1.205, P = 0.0002) than adherers. (C) 2008 Elsevier Inc. All rights reserved.