BICUCULLINE-INDUCED ENHANCEMENT OF SENSORY RESPONSES AND CROSS-CORRELATIONS BETWEEN RETICULAR-FORMATION AND CORTICAL-NEURONS
BICUCULLINE-INDUCED ENHANCEMENT OF SENSORY RESPONSES AND CROSS-CORRELATIONS BETWEEN RETICULAR-FORMATION AND CORTICAL-NEURONS
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DOI：
10.1016/0013-4694(83)90208-0
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
CASPARY, DM
中科院分区：
文献类型：
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作者：
FAINGOLD, CL;HOFFMANN, WE;CASPARY, DM
猫的脑干网状结构（RF）和周十字皮层神经元的视觉、听觉和体感反应通过静脉注射得到增强。给予亚惊厥剂量的荷包牡丹碱。 RF 神经元的增强程度在幅度上稍大一些，并且发生在更大比例的 RF 神经元中。在 70% 的情况下，射频区域的反应潜伏期比皮质区域的反应潜伏期短。同时记录的射频和皮层神经元对相同刺激做出反应的很大一部分表现出一致的惊厥诱发的放电互相关性，这在药物治疗前不存在。延迟和相关性数据与射频可能促进皮质增强的可能性一致。荷包牡丹碱给药可降低射频神经元的听觉反应阈值。先前已观察到其他几种惊厥药物可增强 RF 神经元反应性，这些药物被认为作用于不同的神经递质，这表明它可能反映了这些药物的一般作用，超出了对特定神经递质的作用。荷包牡丹碱诱导的射频和十字交叉神经元放电的相关性可能参与了感觉刺激诱导的惊厥介导的癫痫发作的启动机制。
The visual, auditory and somatosensory responses of neurons in the brain stem reticular formation (RF) and pericruciate cortex of the cat are enhanced by i.v. administration of subconvulsant doses of bicuculline. The degree of enhancement in RF neurons is somewhat greater in magnitude and occurs in a greater percentage of RF neurons. The latency of response is shorter in the RF than in the cortex in 70% of cases. A large percentage of simultaneously recorded RF and cortical neurons which became responsive to the same stimulus exhibited consistent convulsant-induced cross-correlations of firing which were not present before drug treatment. The latency and correlation data are consistent with the possibility that the RF may subserve the cortical enhancement. Auditory response thresholds in RF neurons are reduced by bicuculline administration. Enhancement of RF neuronal responsiveness has previously been observed with several other convulsant drugs which are though to act on different neurotransmitters suggesting that it may reflect a general action of these agents beyond the effects on specific neurotransmitters. The bicuculline-induced correlation of firing of RF and pericruciate neurons may be involved in the mechanism of initiation of convulsant-mediated seizure generalization induced by sensory stimuli.