Oral contraceptives and increased headache prevalence - The Head-HUNT Study
Oral contraceptives and increased headache prevalence - The Head-HUNT Study
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DOI：
10.1212/01.wnl.0000196481.57994.09
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发表时间：
2006-02-14
期刊：
影响因子：
9.9
通讯作者：
Stovner, LJ
中科院分区：
文献类型：
--
作者：
Aegidius, K;Zwart, JA;Stovner, LJ
目的：在一项大型的、横断面的基于人群的研究中，研究使用口服避孕药（OCs）的女性头痛和偏头痛的患病率。方法：在1995-1997年挪威Nord-Trondelag健康研究（HUNT 2）中，46,506名受邀女性中有27,700（60%）回答了头痛问题（Head-HUNT）。在14353名绝经前妇女中，13944名（97%）回答了有关使用避孕药具的问题。结果：在绝经前妇女中，偏头痛（OR = 1.4, 95% CI = 1.2 - 1.7）和非偏头痛（OR = 1.2, 95% CI = 1.0 - 1.4）的头痛与含有雌激素的OCs的报告使用之间存在显著关联。头痛与OCs中雌激素含量之间的显著剂量关系尚未得到证实。头痛与仅含孕激素的OCs之间无显著关联。结论：服用含雌激素口服避孕药的绝经前妇女更容易发生头痛，尤其是偏头痛。
Objective: To examine the prevalence of headache and migraine among women using oral contraceptives (OCs) in a large, cross-sectional population-based study. Methods: In the Nord-Trondelag Health Study in Norway 1995-1997 (HUNT 2), 27,700 (60%) out of 46,506 invited women responded to headache questions (Head-HUNT). Among 14,353 premenopausal women, 13,944 (97%) responded to questions regarding use of contraceptives. Results: There was a significant association between headache and reported use of estrogen-containing OCs in premenopausal women, both for migraine (OR = 1.4, 95% CI = 1.2 to 1.7) and for non-migrainous headache (OR = 1.2, 95% CI = 1.0 to 1.4). A significant dose relationship between headache and the amount of estrogen in the OCs could not be demonstrated. No significant association between headache and OCs containing only gestagen was found. Conclusion: Headache, especially migraine, was more likely among premenopausal women using oral contraceptives containing estrogen.