The association of maternal gestational diabetes mellitus with autism spectrum disorders in the offspring
The association of maternal gestational diabetes mellitus with autism spectrum disorders in the offspring
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DOI：
10.5603/dk.2016.0026
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发表时间：
2016-01-01
影响因子：
0.7
通讯作者：
Kozek, Elzbieta
中科院分区：
文献类型：
--
作者：
Kania, Michal;Herbut, Katarzyna;Kozek, Elzbieta
导论.一些证据表明，妊娠前母体糖尿病暴露与后代患自闭症谱系障碍（ASD）的风险之间存在关联。关于母亲妊娠期糖尿病（GDM）暴露与ASD风险之间关系的信息较少。我们的目的是研究ASD疾病的患病率在后代的母亲诊断为GDM。材料和方法。我们分析了从1999年至2011年在克拉科夫大学医院代谢疾病科治疗的GDM患者（947名女性; 1007名4-16岁儿童）收集的数据。我们进行了电话调查，以收集临床信息和生化参数。我们根据精确二项概率进行显著性检验，以评估GDM母亲的后代ASD患病率是否与波兰0-18岁儿童的流行病学数据不同。我们还检查了是否有任何显着的因素区分有和没有ASD的母亲和子女。在我们的研究中，患有GDM的母亲的后代中ASD的患病率（8/1007）高于波兰0-18岁儿童（17.6/10 000; p = 0.0004）。ASD儿童的母亲的中位孕前BMI（20.862 vs. 23.529）、SBP（110 mm Hg vs. 120 mm Hg）和DBP（70 mm Hg vs. 80 mm Hg）低于无ASD组（分别为p = 0.0349; p = 0.0149和p = 0.0306）。ASD儿童的出生体重显著高于无ASD组（3695 g vs. 3320 g，p = 0.0482）。妊娠期糖尿病母亲的后代ASD的患病率似乎高于一般人群。研究潜在的危险因素对于更好地理解这种现象至关重要，并且可能有助于预防它。
Introduction. Some evidence exists for the association between exposure to pregestational maternal diabetes and risk of autism spectrum disorders (ASD) in offspring. Less information is available on the association of exposure to maternal gestational diabetes mellitus (GDM) with risk of ASD. We aimed to examine the prevalence of ASD disorders in offspring of mothers diagnosed with GDM.Material and methods. We analyzed data gathered from GDM patients (947 women; 1007 children aged 4-16 years) treated at the Department of Metabolic Diseases, University Hospital in Krakow from 1999 to 2011. We conducted a telephone survey to collect clinical information and biochemical parameters. We performed significance test based on the exact binomial probability to assess if the prevalence rate of ASD in offspring of mothers with GDM was different from available epidemiological data for children aged 0-18 years in Poland. We also checked whether there are any significant factors discriminating the mothers and offspring with and without ASD.Results. The prevalence of ASD in the offspring of mothers with GDM in our study (8/1007) was higher than in children aged 0-18 years in Poland (17.6/ /10 000; p = 0.0004). The mothers of children with ASD had median pre-pregnancy BMI (20.862 vs. 23.529), SBP (110 mm Hg vs. 120 mm Hg) and DBP (70 mm Hg vs. 80 mm Hg) lower vs. group without ASD (p = 0.0349; p = 0.0149 and p = 0.0306 respectively). Birth weight of ASD children was significantly higher vs group without ASD (3695 g vs. 3320 g, p = 0.0482).Conclusions. The prevalence of ASD seems to be higher in offspring of mothers with GDM than in the general population. Studying the potential risk factors is crucial for better understanding of this phenomenon and it may be helpful to preventi it.