A rapid blood test to monitor immunity shift during pregnancy and potential application for animal health management.
A rapid blood test to monitor immunity shift during pregnancy and potential application for animal health management.
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一种快速血液检测，用于监测怀孕期间的免疫变化以及动物健康管理的潜在应用。
DOI：
10.1016/j.sintl.2020.100009
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发表时间：
2020
影响因子：
--
通讯作者：
Huo,Qun
中科院分区：
文献类型：
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作者：
Zheng,Tianyu;Moustafa,Yasmine;Finn,Caroline;Scott,Sydney;Haase,ChristopherJ;Carpinelli,NathalyA;Osorio,JohanS;McKinstry,KarlK;Strutt,TaraM;Huo,Qun
农场动物的免疫健康对其整体健康、福利和生产力产生重大影响。对于人类和动物来说，最脆弱的生理状态之一就是怀孕。许多全身变化与妊娠状态相关，包括免疫系统的变化，这可能会影响对病原体挑战的最佳反应能力。因此，能够密切监测怀孕动物的免疫健康状况将是有益的。最近，我们开发了一种新的纳米颗粒快速血液测试，可以检测实验室和农场动物持续的免疫反应。在这里，我们报告说，这种新颖的测试揭示了实验室小鼠和牛与妊娠和围产期相关的高度可重复和急性的变化。我们假设测试分数的变化反映了妊娠女性与体液免疫反应相关的免疫状态的变化。该测试操作简单，成本低，20分钟内即可得出结果。这种快速测试有可能用作当地农场和小型诊所的动物健康管理现场测试。
The immune health of a farm animal can have significant impact on its overall health, welfare and productivity. One of the most vulnerable physiological states for both humans and animals is pregnancy. Many systemic changes correlate with the gravid state, including shifts in the immune system that may impact the ability to respond optimally to pathogen challenge. Because of this, it would be beneficial to be able to monitor the immune health of the pregnant animals closely. Recently, we developed a new nanoparticle-enabled rapid blood test that can detect ongoing immune responses from both laboratory and farm animals. Here, we report that this novel test reveals highly repeatable and acute changes associated with pregnancy and peri-parturition period in laboratory mice and in cattle. We hypothesize that the test score change reflects changes in the immune status of the gravid females related to the humoral immune response. The test is easy to conduct, of low cost, with results obtained in less than 20 min. This rapid test could be potentially used as an onsite test in local farms and small clinics for animal health management.