Cell Assemblies in the Cortico-Hippocampal-Reuniens Network during Slow Oscillations
Cell Assemblies in the Cortico-Hippocampal-Reuniens Network during Slow Oscillations
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DOI：
10.1523/jneurosci.0571-20.2020
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发表时间：
2020-10-21
影响因子：
5.3
通讯作者：
Quilichini, Pascale P.
中科院分区：
文献类型：
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作者：
Angulo-Garcia, David;Ferraris, Maeva;Quilichini, Pascale P.
团结核(NR)是连接内侧前额叶皮质(MPFC)和海马区(HPC)的重要解剖和功能中枢。目前尚不清楚NR是否控制神经元组装，这是HPC和mPFC之间进行记忆转移/巩固的信息交换的标志。通过同步记录雄性大鼠在麻醉状态下慢振荡过程中NR、HPC和mPFC的局部场电位和单位记录，我们发现在UP状态开始时，NR神经元有可靠的顺序激活，先于mPFC激活。从背侧到腹侧的NR序列在空间上是有组织的。NR的化学失活在UP状态开始时扰乱了mPFC序列，以及在尖锐波纹期间存在的HPC序列。我们的结论是，在慢振荡过程中，NR可能通过其自身序列的早期激活而有助于mPFC和HPC神经元序列的协调和稳定。
The nucleus reuniens (NR) is an important anatomic and functional relay between the medial prefrontal cortex (mPFC) and the hippocampus (HPC). Whether the NR controls neuronal assemblies, a hallmark of information exchange between the HPC and mPFC for memory transfer/consolidation, is not known. Using simultaneous local field potential and unit recordings in NR, HPC, and mPFC in male rats during slow oscillations under anesthesia, we identified a reliable sequential activation of NR neurons at the beginning of UP states, which preceded mPFC ones. NR sequences were spatially organized, from dorsal to ventral NR. Chemical inactivation of the NR disrupted mPFC sequences at the onset of UP states as well as HPC sequences present during sharp-wave ripples. We conclude that the NR contributes to the coordination and stabilization of mPFC and HPC neuronal sequences during slow oscillations, possibly via the early activation of its own sequences.