DISTURBED IRON-METABOLISM AMONG WORKERS EXPOSED TO ORGANIC SULFIDES IN A PULP PLANT
DISTURBED IRON-METABOLISM AMONG WORKERS EXPOSED TO ORGANIC SULFIDES IN A PULP PLANT
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DOI：
10.5271/sjweh.1956
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发表时间：
1988-02-01
影响因子：
6.3
通讯作者：
TENHUNEN, R
中科院分区：
文献类型：
--
作者：
KLINGBERG, J;BEVIZ, A;TENHUNEN, R
本研究的目的是调查接触硫化物和血红素和红细胞的合成障碍之间的可能关系。18名工人暴露于硫化物的纸浆和造纸厂进行了检查，并与单独匹配的参考从热磨机械纸浆厂没有这样的接触。甲硫醇、二甲硫醚和二甲基二硫醚的暴露水平较低。然而，五名受试者暴露于高水平的shrot持续时间，他们的数据进行了单独分析。分析网织红细胞中δ-氨基乙酰丙酸合成酶和血红素合成酶的活性、红细胞的特征和铁状况。在5名高暴露受试者中，观察到酶略有下降，但无统计学显著性。然而，与参照物的相应水平相比，铁和转铁蛋白的浓度升高，铁蛋白的浓度较低。这种结合不会自发发生。以前的研究表明，硫化物可能会抑制血红素的合成，本研究表明，他们也可能会干扰铁代谢。
The aim of this study was to investigate a possible relationship between exposure to sulfides and disturbances of the synthesis of heme and the erythrocytes. Eighteen workers exposed to sulfides at a pulp and paper plant were examined and compared with individually matched referents from a thermomechanical pulp plant without such exposure. The exposure levels of methylmercaptan, dimethylsulfide, and dimethyldisulfide were low. However, five subjects were exposed to high levels of shrot duration, and their data were analyzed separately. The activity of the enzymes delta-aminolevulinic acid synthase and heme synthase in reticulocytes, characteristics of the erythrocytes, and the iron status were analyzed. A minor decrease, not statistically significant, was observed for the enzymes among the five highy exposed subjects. However, the concentrations of iron and transferrin were elevated and the concentration of ferritin was low in comparison to the corresponding levels of the referents. This combination will not occur spontaneously. A previous study indicated that sulfides may inhibit heme synthesis, and the present study suggests that they may also disturb iron metabolism.