Storing and analyzing a genome on a blockchain.
Storing and analyzing a genome on a blockchain.
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DOI：
10.1186/s13059-022-02699-7
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发表时间：
2022-06-29
期刊：
影响因子：
12.3
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中科院分区：
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人们正在努力使基因组测序成为临床实践的常规部分。实现这些目标的一个关键障碍是实现数据所有权和完整性的实用解决方案。区块链为金融等其他领域的这些挑战提供了解决方案。然而，由于难以在链上存储大规模数据，交易速度慢以及查询限制，它在基因组学中的应用受到阻碍。为了克服这些障碍，我们开发了一个私有区块链网络来存储基因组变异和链上参考比对的reads。它使用嵌套数据库索引和附带的工具套件来快速访问和分析数据。在线版本包含补充材料，下载地址：10.1186/s13059-022-02699-7。
There are major efforts underway to make genome sequencing a routine part of clinical practice. A critical barrier to these is achieving practical solutions for data ownership and integrity. Blockchain provides solutions to these challenges in other realms, such as finance. However, its use in genomics is stymied due to the difficulty in storing large-scale data on-chain, slow transaction speeds, and limitations on querying. To overcome these roadblocks, we developed a private blockchain network to store genomic variants and reference-aligned reads on-chain. It uses nested database indexing with an accompanying tool suite to rapidly access and analyze the data. The online version contains supplementary material available at 10.1186/s13059-022-02699-7.