MENISCAL REPAIR USING FIBRIN SEALANT AND ENDOTHELIAL-CELL GROWTH-FACTOR - AN EXPERIMENTAL-STUDY IN DOGS
MENISCAL REPAIR USING FIBRIN SEALANT AND ENDOTHELIAL-CELL GROWTH-FACTOR - AN EXPERIMENTAL-STUDY IN DOGS
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DOI：
10.1177/036354659202000509
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发表时间：
1992-09-01
影响因子：
4.8
通讯作者：
HIROHATA, K
中科院分区：
文献类型：
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作者：
HASHIMOTO, J;KUROSAKA, M;HIROHATA, K
在15只成年杂种犬30侧半月板上，观察了纤维蛋白封闭剂和内皮细胞生长因子对半月板缺血区愈合的影响。分别采用三种方法进行修复：1组，空白；2组，填充纤维蛋白封闭剂；3组，填充纤维蛋白封闭剂和内皮细胞生长因子。每隔1、2、6、12和24周对愈合过程进行大体和组织学评估。平均每个缺损处充满结缔组织的比例分别为5%、76.6%和89.4%。在修复早期，含有大量毛细血管的外源性血管圈样组织从半月板滑膜交界处延伸至缺损区。随后，形成有组织的纤维结缔组织，在12~24周时已转变为软骨组织。纤维蛋白封闭剂和内皮细胞生长因子的结合促进了新生血管和肉芽组织的形成，这是半月板无血管部分愈合水平提高的原因。
The effect of fibrin sealant and endothelial cell growth factor on the healing of defects of the avascular portion of canine menisci was investigated in 30 menisci of 15 adult mongrel dogs. The defects were treated in one of three ways: Group 1, the defect was left empty; Group 2, the defect was filled with fibrin sealant; and Group 3, the defect was filled with fibrin sealant and endothelial cell growth factor. The healing process was evaluated macroscopically and histologically at intervals of 1, 2, 6, 12, and 24 weeks. The average percentage of each defect that was filled with connective tissue was 5% in Group 1, 76.6% in Group 2, and 89.4% in Group 3. In the early phase of this repair, the extrinsic pannus-like tissue that contained many capillary vessels extended from the meniscosynovial junction into the defect. Subsequently, organized fibrous connective tissue was formed, which had changed to cartilaginous tissue at 12 to 24 weeks. The combination of fibrin sealant and endothelial cell growth factor enhanced the neovascularization and formation of granulation tissue, which accounted for the increased healing level in the avascular portion of the meniscus.