Integrin signaling and cell growth control
Integrin signaling and cell growth control
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DOI：
10.1016/s0955-0674(98)80144-0
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发表时间：
1998-04-01
影响因子：
7.5
通讯作者：
Juliano, RL
中科院分区：
文献类型：
--
作者：
Howe, A;Aplin, AE;Juliano, RL
整联蛋白通过在细胞骨架结构和细胞外基质之间提供物理连接以及还通过参与各种信号转导过程来促进细胞生长。整联蛋白与基质配体的相互作用可以在其自身内产生信号，并且还可以调节由可溶性因子如肽有丝分裂原引发的信号。受整合素介导的信号传导影响的细胞事件包括运动性、细胞分裂、分化和程序性细胞死亡。阐明整合素介导的细胞粘附如何控制细胞生长可能对理解复杂的生物学过程（如组织形态发生和肿瘤进展）具有根本重要性。(C)Current Biology Ltd ISSN 0955-0674。
Integrins contribute to cell growth by providing a physical linkage between cytoskeletal structures and the extracellular matrix, and also by participating in various signal transduction processes, The interaction of integrins with matrix ligands can generate signals in and of itself, and can also modulate signals instigated by soluble factors such as peptide mitogens. Cellular events affected by integrin-mediated signaling include motility, cell division, differentiation and programmed cell death. Elucidation of how integrin-mediated cell adhesion controls cell growth is likely to be of fundamental importance in understanding complex biological processes, such as tissue morphogenesis and tumor progression. (C) Current Biology Ltd ISSN 0955-0674.