Examination of the early wound healing process under different wound dressing conditions
Examination of the early wound healing process under different wound dressing conditions
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DOI：
10.1016/j.oooo.2016.10.023
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发表时间：
2017-03-01
影响因子：
2.9
通讯作者：
Nakamura, Norifumi
中科院分区：
文献类型：
--
作者：
Kibe, Toshiro;Koga, Takashi;Nakamura, Norifumi
Objective.各种类型的伤口愈合敷料已被用于帮助手术伤口的愈合。我们在动物模型中分析了使用不同现有伤口敷料的伤口愈合过程。在7周龄大鼠背部使用活检穿孔器制造全层缺损。使用大鼠夹克固定NEOVEIL（聚乙醇酸[PGA]）或TERUDERMIS（胶原海绵[CS]）覆盖受伤区域。比较对照组、PGA组和CS组的创面面积、新生上皮长度和α-平滑肌肌动蛋白（α-SMA）表达。对照组第4天和第7天的伤口面积明显小于PGA组和CS组。对于所有组，α-SMA在肉芽组织中的表达在第4天达到峰值。对照组在伤后第4天和第7天的α-SMA表达高于PGA组和CS组。PGA组和CS组间a-SMA表达无显著性差异。在这项研究中，PGA和CS抑制伤口挛缩并减少伤口区域中的α-SMA的表达。然而，PGA和CS不影响伤口部位的新生上皮长度。
Objective. Various types of wound-healing dressings have been used to assist in the healing of surgical wounds. We analyzed the wound-healing process in an animal model using different existing wound dressings.Study design. Full-thickness defects were created using a biopsy punch on the backs of 7-week-old rats. The wounded areas were covered with NEOVEIL (polyglycolic acid [PGA]) or TERUDERMIS (collagen sponge [CS]) affixed using a rat jacket. The wound area, neo-epithelium length, and a-smooth muscle actin (a-SMA) expression were evaluated and compared among the control, PGA, and CS groups.Results. The wound areas in the control group on days 4 and 7 were significantly smaller than those in the PGA and CS groups. The expression of a-SMA in granulation tissue peaked on day 4 for all groups. The expression of a-SMA in the control group on days 4 and 7 after injury was greater than in the PGA and CS groups. However, there was no significant difference in the expression of a-SMA between the PGA and CS groups.Conclusions. In this study, PGA and CS suppressed wound contracture and reduced expression of a-SMA in wound areas. However, PGA and CS did not affect the neo-epithelium length at the wound site.