Comparative Evaluation of Endotoxin Activity Level and Various Biomarkers for Infection and Outcome of ICU-Admitted Patients
Comparative Evaluation of Endotoxin Activity Level and Various Biomarkers for Infection and Outcome of ICU-Admitted Patients
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DOI：
10.3390/biomedicines7030047
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发表时间：
2019-09-01
期刊：
影响因子：
4.7
通讯作者：
Wajima, Zen'ichiro
中科院分区：
文献类型：
--
作者：
Ikeda, Toshiaki;Kamohara, Hidenobu;Wajima, Zen'ichiro
在这里，我们同时测量了患者进入重症监护室（ICU）后24小时内获得的血液中的内毒素活性（EA）水平和多种生物标志物的水平，并分析了这些标志物之间是否存在联系及其与患者病情和结局的相关性。EA水平与疾病严重程度和患者生存率高度相关，并与乳酸盐、原降钙素、前敏素和白细胞介素-6水平显着正相关。值得注意的是，EA水平是与血培养结果最高度相关的标志物，而前体蛋白水平是与28天时的生存结果最高度相关的标志物。因此，最佳生物标志物的选择应基于其是否将用于区分感染的存在或预测存活。
Here, we concurrently measured the endotoxin activity (EA) level and levels of multiple biomarkers in patient blood obtained within 24 h after being admitted into the intensive care unit (ICU) and analyzed whether there were links between these markers and their associations with patient conditions and outcomes. The EA levels highly correlated with disease severity and patient survival, and showed a significant positive association with levels of lactate, procalcitonin, presepsin, and interleukin-6. Notably, the EA level was the marker that most highly correlated with the results of blood culture, and the presepsin level was the marker most highly correlated with the survival outcome at 28 days. Thus, the optimal biomarker should be selected based on whether it will be used to discriminate the presence of an infection or to predict survival.