Dysregulated expression of Slug, vimentin, and E-cadherin correlates with poor clinical outcome in patients with basal-like breast cancer
Dysregulated expression of Slug, vimentin, and E-cadherin correlates with poor clinical outcome in patients with basal-like breast cancer
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DOI：
10.1002/jso.23240
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发表时间：
2013-02-01
影响因子：
2.5
通讯作者：
Pang, Da
中科院分区：
文献类型：
--
作者：
Liu, Tong;Zhang, Xianyu;Pang, Da
背景在不同类型的乳腺癌中，基底细胞样乳腺癌（BLBC）因其高复发率和高转移率而预后极差。本研究旨在探讨Slug、E-cadherin和vimentin的表达与BLBC患者临床病理特征和预后的关系。我们进一步从这些发现中推断Slug是否通过上皮间质转化（EMT）导致BLBC患者预后不良。方法采用免疫组化法检测441例乳腺癌组织中Slug、E-cadherin和vimentin的表达。评估蛋白表达与BLBC患者临床病理特征的相关性，并随访这些患者以确定生存率。结果BLBC组织中Slug高表达和E-cadherin低表达与组织学分级、淋巴结转移、TNM分期和淋巴管转移密切相关。生存分析显示，BLBC的不良预后与TNM分期、Slug和vimentin高表达以及E-cadherin低水平有关。结论BLBC患者Slug蛋白高表达与预后不良密切相关。我们推测，这可能是由于鼻涕虫在BLBC的EMT的参与。《肿瘤外科杂志》2013;107：188194. (c)2012年威利期刊公司
Background Among the different types of breast cancer, basal-like breast cancer (BLBC) has an extremely poor prognosis due to its high rate of recurrence and metastasis. The present study aimed to investigate the correlation between the expression of Slug, E-cadherin, and vimentin, and the clinicopathological characteristics and prognosis of patients with BLBC. We further inferred from these findings whether Slug leads to a poor prognosis in patients with BLBC through epithelialmesenchymal transition (EMT). Methods Immunohistochemistry was performed for 441 patients with breast cancer to determine the expression levels of Slug, E-cadherin, and vimentin. The correlation between protein expression and clinicopathological characteristics of patients with BLBC was evaluated, and these patients were followed up to determine survival rate. Results High Slug and low E-cadherin expression in BLBC patients closely correlated with histological grade, lymph node metastasis, tumor-node-metastasis (TNM) stage, and lymphatic vessel metastasis. Survival analysis revealed that the poor prognosis of BLBC is associated with TNM stage, high Slug and vimentin expression, and low E-cadherin levels. Conclusions High Slug expression is closely correlated with poor prognosis in patients with BLBC. We speculate that this may be attributed to the involvement of Slug in the EMT of BLBC. J. Surg. Oncol. 2013;107:188194. (c) 2012 Wiley Periodicals, Inc.