Transcranial application of low-energy laser irradiation improves neurological deficits in rats following acute stroke
Transcranial application of low-energy laser irradiation improves neurological deficits in rats following acute stroke
复制标题
DOI：
10.1002/lsm.20256
复制
发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Streeter, J
中科院分区：
文献类型：
--
作者：
DeTaboada, L;Ilic, S;Streeter, J
背景和目的：低水平激光治疗（LLLT）已被证明对缺血性骨骼肌和心肌组织有有益的影响。本研究的目的是在急性中风大鼠的大脑不同部位批准LLLT治疗的有效性。研究设计/材料和方法：169只大鼠被诱导中风，分为四组：对照组，非激光治疗组和三个激光治疗组，其中激光在诱导中风的同侧，对侧和两侧使用。对大鼠进行了神经功能测试。结果：在所有三个激光治疗组中，与未治疗组相比，中风后14,21和28天的神经功能缺损明显改善。结论：这些观察结果表明，在脑卒中后较晚的阶段应用颅骨不同位置的LLLT可有效改善大鼠急性脑卒中后的神经功能。
Background and Objectives: Low-level laser therapy (LLLT) has been shown to have beneficial effects on ischemic skeletal and heart muscles tissues. The aim of the present study was to approve the effectiveness of LLLT treatment at different locations on the brain in acute stroked rats.Study Design/Materials and Methods: Stroke was induced in 169 rats that were divided into four groups: control non-laser and three laser-treated groups where laser was employed ipsilateral, contralateral, and both to the side of the induced stroke. Rats were tested for neurological function.Results: In all three laser-treated groups, a marked and significant improvement in neurological deficits was evident at 14, 21, and 28 days post stroke relative to the non-treated group.Conclusions: These observations suggest that LLLT applied at different locations in the skull and in a rather delayed-phase post stroke effectively improves neurological function after acute stroke in rats.