DEVELOPMENT OF A CIRCADIAN-RHYTHM IN ACTIVITY OF PINEAL SEROTONIN N-ACETYLTRANSFERASE
DEVELOPMENT OF A CIRCADIAN-RHYTHM IN ACTIVITY OF PINEAL SEROTONIN N-ACETYLTRANSFERASE
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DOI：
10.1111/j.1471-4159.1972.tb01458.x
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发表时间：
1972-01-01
影响因子：
4.7
通讯作者：
KLEIN, DC
中科院分区：
文献类型：
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作者：
ELLISON, N;WELLER, JL;KLEIN, DC
松果体5-羟色胺N-乙酰转移酶(EC 2.3.1.5)是一种神经调节酶。早在老鼠出生前4天，就可以在老鼠身上检测到这种病毒。酶活性在出生后第四天出现昼夜节律。它在第二周发育最快，到第三周结束时达到成虫量级，此时夜间的值是白天的30多倍。去甲肾上腺素似乎是调节这种酶的神经递质，它可以导致4天龄动物松果腺器官培养中N-乙酰转移酶的2-3倍刺激，15天龄动物松果腺活性增加17倍。显然，控制松果体N-乙酰转移酶活性的去甲肾上腺素敏感系统在生命的最初几周也发展得最快。5-羟色胺N-乙酰转移酶活性的昼夜节律在雄性和雌性大鼠的松果腺中以相同的速度发展。这种酶的类似节律在大鼠的其他12个组织中没有观察到。
Pineal serotoninN‐acetyltransferase (EC 2.3.1.5) is a neurally regulated enzyme. It is detectable in the rat as early as 4 days prior to birth. A circadian rhythm in enzyme activity appears on the fourth day after birth. It develops most rapidly during the second week and achieves an adult magnitude by the end of the third week at which time nocturnal values are more than 30‐fold greater than daytime values. Norepinephrine, which appears to be the neurotransmitter regulating this enzyme, can cause a 2‐ to 3‐fold stimulation ofN‐acetyltransferase in organ cultures of pineal glands from 4‐day‐old animals and a 17‐fold increase in the activity of glands from 15‐day‐old animals. Apparently the norepinephrinesensitive system controlling pinealN‐acetyltransferase activity also develops most rapidly during the first few weeks of life. The circadian rhythm in the activity of serotoninN‐acetyltransferase develops in the pineal glands of both male and female rats at the same rate. A similar rhythm for the enzyme was not observed in twelve other tissues of the rat.