Selective Incorporation of Difluoromethylene Moieties into Arenes Assisted by Transition Metals
Selective Incorporation of Difluoromethylene Moieties into Arenes Assisted by Transition Metals
复制标题
过渡金属辅助下选择性地将二氟亚甲基部分掺入芳烃中
DOI：
10.2533/chimia.2014.414
复制
发表时间：
2014-01-01
期刊：
影响因子：
1.2
通讯作者：
Hu, Jinbo
中科院分区：
文献类型：
--
作者：
Gao, Bing;Ni, Chuanfa;Hu, Jinbo
Fluorinated compounds are of significant importance in various fields due to their unique chemical, physical, and biological properties. Accordingly, the incorporation of fluorine atom(s) or fluorine-containing functionalities into organic molecules has received considerable attention. For decades, extensive reports and reviews mainly focused on the fluorination and perfluoroalkylation (especially trifluoromethylation) whereas the preparation of partially fluorinated compounds was less developed. Difluoromethylated arenes and their derivatives (ArCF2R, R not equal F, R-f, H) have been found to be as important in pharmaceuticals as trifluoromethylated arenes. However, it is only recently that these compounds have experienced a revival of interest from synthetic chemists. The direct construction of carbon(sp(2)) carbon(sp(3)) bonds via transition metal-mediated cross-coupling reactions represents one of the most straightforward strategies for the introduction of difluoromethylene moieties (CF2R, R not equal F, R-f) to aromatic compounds. This mini-review focuses on recent advances of this research topic from both synthetic and mechanistic perspectives.
