MACROPHAGE INFLAMMATORY PROTEIN .1. A PROSTAGLANDIN-INDEPENDENT ENDOGENOUS PYROGEN
MACROPHAGE INFLAMMATORY PROTEIN .1. A PROSTAGLANDIN-INDEPENDENT ENDOGENOUS PYROGEN
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DOI：
10.1126/science.2646711
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发表时间：
1989-02-24
期刊：
影响因子：
56.9
通讯作者：
CERAMI, A
中科院分区：
文献类型：
--
作者：
DAVATELIS, G;WOLPE, SD;CERAMI, A
巨噬细胞炎性蛋白-1（MIP-1）产生了一种快速发作的阶段性发热，其幅度等于或大于重组人恶病质（或肿瘤坏死因子）或重组人白细胞介素-1产生的发热。然而，与这两种内源性热原相反，MIP-1引起的发热不受环氧合酶抑制剂布洛芬的抑制。因此，MIP-1可能参与发热反应，而发热反应不是通过前列腺素合成介导的，临床上不能用环氧合酶抑制剂消除。
Macrophage inflammatory protein-1 (MIP-1) produced a monophasic fever of rapid onset whose magnitude was equal to or greater than that of fevers produced with either recombinant human cachectin (or tumor necrosis factor) or recombinant human interleukin-1. However, in contrast to these ttwo endogenous pyrogens, the fever induced by MIP-1 was not inhibited by the cyclooxygenase inhibitor ibuprofen. Thus, MIP-1 may participate in the febrile response response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase inhibitors.