Altered surface tension of lung extracts and lung mechanics
Altered surface tension of lung extracts and lung mechanics
复制标题
改变肺提取物的表面张力和肺力学
DOI：
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发表时间：
1965
期刊：
影响因子：
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通讯作者：
R. Johnson
中科院分区：
文献类型：
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作者：
D. Tierney;R. Johnson
将 24 种兔肺提取物的表面积减少五分之四，使表面张力在 18-22°C 时降至最小值 0-5 达因/厘米。然而，如果 1) 温度升至 42°C，2) 用蒸馏水制备提取物，3) 将磷脂酶 C 与提取物一起孵育，4) 加入胆固醇或油酸，则最小表面张力将高于 15 达因/厘米。添加到 表面。如果在提取过程中添加血液或血清，则最小表面张力通常（尽管并非总是）升高。通过气道冲洗稀释的大鼠血清或乳糜微粒会增加离体大鼠肺部的弹性回缩力。其他报告表明，将肺部加热至 42°C 以上或通过气道冲洗磷脂酶 C 溶液也会增加离体大鼠肺部的弹性反冲力。因此，这些条件一致地改变了肺提取物的表面张力和肺的压力-容积特征。此外，我们发现肺提取物的表面张力在低于 24 达因/厘米时不稳定。如果维持较低的跨肺压，肺内表面的类似不稳定性会导致逐渐的肺不张。
弹性反冲力；肺不张;遵守;肺表面
1965 年 1 月 21 日提交
Reduction of the surface area of 24 extracts of rabbit lungs by four-fifths decreased the surface tension to a minimum value of 0–5 dynes/cm at 18–22 C. However, minimum surface tension was above 15 dynes/cm if 1) the temperature was raised to 42 C, 2) the extract was prepared with distilled water, 3) phospholipase C was incubated with the extract, and 4) cholesterol or oleic acid was added to the surface. If blood or serum was added during the extraction, minimum surface tension was usually (although not invariably) elevated. Rinsing diluted rat serum or chylomicrons through the airways increases elastic recoil of excised rat lungs. Other reports show that heating a lung above 42 C or rinsing a solution of phospholipase C through the airways also increases elastic recoil of excised rat lungs. Therefore, these conditions alter the surface tension of lung extracts and the pressure-volume characteristics of the lungs concordantly. In addition, we found that the surface tension of lung extracts was not stable below 24 dynes/cm. Similar instability of the surface within the lung should lead to gradual atelectasis if a low transpulmonary pressure is maintained.
elastic recoil; atelectasis; compliance; lung surface
Submitted on January 21, 1965